{"id":"W2295805773","doi":"10.1182/blood-2015-10-676924","title":"Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Vascular Malformations Diagnosis and Treatment","field":"Medicine","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; Medical Research Council; European Commission","keywords":"Defibrotide; Medicine; Hepatic veno-occlusive disease; Disease; Internal medicine; Surgery; Intensive care medicine; Hematopoietic stem cell transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001883211,0.001094976,0.001472398,0.0003017966,0.0003951422,0.0007685489,0.0005354083,0.001278755,0.004092512],"category_scores_gemma":[0.001273017,0.0003248552,0.001335566,0.0002357248,0.0005445485,0.0006482821,0.0003010767,0.002518046,0.0006380897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005278903,"about_ca_system_score_gemma":0.0009324853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006243346,"about_ca_topic_score_gemma":0.00157256,"domain_scores_codex":[0.9996383,0.0002147756,0.00001372222,0.000042483,0.00003215835,0.00005858361],"domain_scores_gemma":[0.9993825,0.0001660507,0.0001535722,0.00005541233,0.00004166792,0.0002007725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8841161,0.02276033,0.003213817,0.0005626492,0.00103557,0.000317772,0.0001566833,0.001259138,0.0219771,0.00067269,0.005728145,0.05819991],"study_design_scores_gemma":[0.8280236,0.1576888,0.008056852,0.00005516593,0.0002377458,0.0002852443,0.00003184822,0.001242375,0.001422262,0.0004297716,0.002500033,0.00002628813],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846166,0.003244024,0.001133504,0.001056373,0.0003383214,0.004144182,0.001763464,0.000179903,0.003523563],"genre_scores_gemma":[0.9804322,0.001978031,0.00271385,0.002515815,0.00033215,0.005321894,0.003233331,0.0000407935,0.003431961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004092512,"threshold_uncertainty_score":0.01369083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02147483339435223,"score_gpt":0.2910748467229818,"score_spread":0.2696000133286295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}