{"id":"W2296384316","doi":"10.1074/jbc.m115.663518","title":"IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of Dental and Craniofacial Research","keywords":"RANKL; Osteoclast; Cell biology; RANK Ligand; Signal transduction; Activator (genetics); Biology; Transcription factor; Receptor; TLR2; Chemistry; Cancer research; TLR4; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840945,0.000391105,0.0003491725,0.0002245731,0.0001473522,0.0003014857,0.000190164,0.0003229266,0.001038948],"category_scores_gemma":[0.0001279106,0.0001689579,0.0003593305,0.0001415477,0.0002578412,0.0002725696,0.0002906362,0.0007300594,0.0003899795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140755,"about_ca_system_score_gemma":0.0002404573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002029736,"about_ca_topic_score_gemma":0.0004186522,"domain_scores_codex":[0.9996623,0.00005624601,0.00003404155,0.00006206717,0.00007725069,0.0001081134],"domain_scores_gemma":[0.9999254,0.0000056074,0.00003049556,0.000006339351,0.00001072695,0.0000214657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004933605,0.00005405826,0.0004698843,0.00008175058,0.000006696636,0.00008476938,0.00001856446,0.00004836019,0.9968131,0.00008448151,0.00005128208,0.001793686],"study_design_scores_gemma":[0.0002826526,0.002178992,0.05163401,0.00004367216,0.0001287963,0.002093293,0.0002056204,0.002056979,0.9342049,0.0002700343,0.006877753,0.00002331021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990213,0.004358325,0.003052094,0.0002015575,0.00006195683,0.0000513674,0.0004498285,0.0000482732,0.001563625],"genre_scores_gemma":[0.9924259,0.00170394,0.002343914,0.0001909442,0.00003320787,0.00008098977,0.0005403354,0.00001300893,0.00266785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038948,"threshold_uncertainty_score":0.003475606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03260286501493524,"score_gpt":0.248166847892947,"score_spread":0.2155639828780118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}