{"id":"W2296384316","doi":"10.1074/jbc.m115.663518","title":"IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of Dental and Craniofacial Research","keywords":"RANKL; Osteoclast; Cell biology; RANK Ligand; Signal transduction; Activator (genetics); Biology; Transcription factor; Receptor; TLR2; Chemistry; Cancer research; TLR4; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001297656,0.0002054174,0.0003994231,0.0000192649,0.00004106225,0.00001604379,0.0001852218,0.0003584764,0.0000489013],"category_scores_gemma":[0.0002369603,0.000149523,0.0001729322,0.0001087664,0.0001451653,0.00003361589,0.000124692,0.00009347679,9.098384e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002756363,"about_ca_system_score_gemma":0.0001192352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001290916,"about_ca_topic_score_gemma":2.176042e-7,"domain_scores_codex":[0.9987079,0.00007732926,0.0005589682,0.0002441607,0.0002360288,0.0001756137],"domain_scores_gemma":[0.9985065,0.00001912582,0.0007294063,0.000214069,0.0003944016,0.0001364577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001262732,0.0001638465,0.000547616,0.00007333411,0.00008465001,0.000002307198,0.00008233551,0.00004150403,0.9971858,0.000009533243,0.000131669,0.0004146591],"study_design_scores_gemma":[0.001131215,0.0004838074,0.005080036,0.00004427876,0.00004495119,0.0000246635,0.0002317328,0.00001403898,0.9914958,0.0002651931,0.001018874,0.0001653374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979469,0.00144175,0.00009025155,0.00005100923,0.0000856777,0.0001305907,0.00008894587,0.000007054007,0.000157885],"genre_scores_gemma":[0.9981994,0.0004071733,0.001050636,0.00003248482,0.0002093005,0.000002235555,0.00004500023,0.00001459944,0.00003918129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005689943,"threshold_uncertainty_score":0.6097371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03260286501493524,"score_gpt":0.248166847892947,"score_spread":0.2155639828780118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}