{"id":"W2296429206","doi":"10.1111/mmi.13352","title":"The cystathionine‐<i>β</i>‐synthase domains on the guanosine 5′’‐monophosphate reductase and inosine 5′‐monophosphate dehydrogenase enzymes from <i>Leishmania</i> regulate enzymatic activity in response to guanylate and adenylate nucleotide levels","year":2016,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biochemistry; Biology; Guanosine monophosphate; Adenylate kinase; Inosine; Guanosine; Enzyme; GTP'; Guanylate kinase; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001115815,0.0005229504,0.0004194829,0.0001051715,0.000342761,0.0001091046,0.0005563599,0.0003498937,0.00002220043],"category_scores_gemma":[0.0007893441,0.0003024642,0.000119201,0.00029981,0.0007967203,0.00001417789,0.000770562,0.0003308651,0.0000354644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006125886,"about_ca_system_score_gemma":0.0001144913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001135358,"about_ca_topic_score_gemma":0.00006566192,"domain_scores_codex":[0.9962993,0.001031992,0.0004823495,0.001133756,0.000161648,0.0008909666],"domain_scores_gemma":[0.9979069,0.0004292576,0.0001677334,0.001073292,0.0001188855,0.000303886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003933388,0.00009595091,0.00006371086,0.00001126373,0.0001251434,0.000180794,0.00006272041,0.00000684514,0.9907385,0.0002864409,0.001341414,0.003153813],"study_design_scores_gemma":[0.001814677,0.0005774831,0.001078842,0.0001124591,0.00003038315,0.0001042297,0.00002187461,0.0000148188,0.9772192,0.0004124743,0.01817802,0.0004355105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760307,0.005432796,0.0003405616,0.01678549,0.0001082516,0.0008801227,0.000370257,0.00002390496,0.00002793558],"genre_scores_gemma":[0.9958922,0.0008295219,0.0003212591,0.002259573,0.00004880063,0.0001238858,0.00004730602,0.00007387954,0.0004035237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01986157,"threshold_uncertainty_score":0.9999427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008040725043133232,"score_gpt":0.2327859992664909,"score_spread":0.2247452742233577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}