{"id":"W2296429206","doi":"10.1111/mmi.13352","title":"The cystathionine‐<i>β</i>‐synthase domains on the guanosine 5′’‐monophosphate reductase and inosine 5′‐monophosphate dehydrogenase enzymes from <i>Leishmania</i> regulate enzymatic activity in response to guanylate and adenylate nucleotide levels","year":2016,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biochemistry; Biology; Guanosine monophosphate; Adenylate kinase; Inosine; Guanosine; Enzyme; GTP'; Guanylate kinase; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009280654,0.000340492,0.000185254,0.0001169519,0.0001136862,0.0002195398,0.000197731,0.0001889732,0.0006731113],"category_scores_gemma":[0.0001414308,0.0001529775,0.0002136324,0.0001138688,0.0002348334,0.0001716062,0.0001820516,0.0003690786,0.0004594997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847228,"about_ca_system_score_gemma":0.0002139416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007535675,"about_ca_topic_score_gemma":0.0006155167,"domain_scores_codex":[0.9999095,0.00001738896,0.000006315651,0.00002514408,0.00002034551,0.00002129194],"domain_scores_gemma":[0.9998881,0.00001340576,0.00003490855,0.00001273787,0.00002095563,0.00002985818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000424016,0.000006451629,0.0001642462,0.0000184392,0.000002203702,0.00003313875,0.000009482646,0.00001839994,0.9986664,0.0001264414,0.00001309997,0.000899242],"study_design_scores_gemma":[0.00000985603,0.000124184,0.006323164,0.000006118062,0.000008861605,0.0004889339,0.00002949657,0.0003744976,0.9894236,0.00007653389,0.003130211,0.000004562029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899033,0.001595014,0.005468624,0.0001032268,0.00001946433,0.00003401345,0.0002677269,0.00009071958,0.002517916],"genre_scores_gemma":[0.9918452,0.0006189739,0.003842107,0.00004893856,0.000007096611,0.0000226765,0.001178926,0.00002253903,0.002413554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007535675,"threshold_uncertainty_score":0.002251804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008040725043133232,"score_gpt":0.2327859992664909,"score_spread":0.2247452742233577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}