{"id":"W2296550515","doi":"10.1038/ng.3526","title":"The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons","year":2016,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":671,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Human Genome Research Institute; National Institute of General Medical Sciences; Biomedical Research Council; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Japan Society for the Promotion of Science; Directorate for Biological Sciences; Volkswagen Foundation; National Institutes of Health; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Ministry of National Education and Religious Affairs; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; National Natural Science Foundation of China; Agency for Science, Technology and Research; Broad Institute; European Molecular Biology Laboratory; University of Oregon; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Alexander von Humboldt-Stiftung; National Key Research and Development Program of China; Brinson Foundation; University of Chicago; Harvard University; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Science Foundation","keywords":"Biology; Genome; Subfunctionalization; Vertebrate; Hox gene; Evolutionary biology; Lineage (genetic); Gene duplication; Gene; Genetics; Genome evolution; Human genome; Comparative genomics; Gene family; Genomics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005889104,0.0003153055,0.0003235959,0.001212348,0.0002743228,0.0007148127,0.0003312439,0.0005783442,0.003351535],"category_scores_gemma":[0.0009608485,0.0002134611,0.000348967,0.0007181187,0.00030887,0.0003492393,0.000801603,0.0007015534,0.0007516841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002010676,"about_ca_system_score_gemma":0.000258191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007448554,"about_ca_topic_score_gemma":0.00295571,"domain_scores_codex":[0.9997603,0.00004646071,0.00001333155,0.00006817395,0.00007600032,0.00003564224],"domain_scores_gemma":[0.9994972,0.0001940022,0.00007146864,0.00006646424,0.00008926555,0.00008156039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001899107,0.0001216815,0.02889291,0.0008028997,0.0003080844,0.001918283,0.0008894836,0.001390103,0.6343552,0.006536571,0.01649632,0.3063895],"study_design_scores_gemma":[0.0003112035,0.0004570959,0.2471446,0.0004404938,0.000590672,0.006634346,0.0009009095,0.006323966,0.1905226,0.01637337,0.5301807,0.0001200246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.894655,0.01937327,0.04711058,0.007190722,0.001137133,0.00008488503,0.009176276,0.002310307,0.01896175],"genre_scores_gemma":[0.9019631,0.008255368,0.07503387,0.00215553,0.0005823167,0.00006831345,0.007084789,0.0005854131,0.004271291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003351535,"threshold_uncertainty_score":0.01121199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007567963335081685,"score_gpt":0.2642849869387203,"score_spread":0.2567170236036386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}