{"id":"W2296581273","doi":"10.21037/tau.2016.02.01","title":"Predicting response to neoadjuvant chemotherapy in bladder cancer: controversies remain with genomic DNA sequencing","year":2016,"lang":"en","type":"article","venue":"Translational Andrology and Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Bladder cancer; Cisplatin; Chemotherapy; Medicine; Complete response; Oncology; Pathological; DNA sequencing; Biomarker; Neoadjuvant therapy; Internal medicine; Cancer; Bioinformatics; DNA; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921646,0.0001373305,0.0002880328,0.0001287995,0.00006230945,0.000002871622,0.00003640731,0.0001258873,0.0002351139],"category_scores_gemma":[0.00002185494,0.00008748109,0.00002771663,0.00007759035,0.0001535208,0.00005124377,0.000006476759,0.00009890367,0.000006231764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005184676,"about_ca_system_score_gemma":0.0002279104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001261722,"about_ca_topic_score_gemma":0.0006275693,"domain_scores_codex":[0.9990712,0.00009823692,0.0001786461,0.0003000454,0.00008223278,0.0002696153],"domain_scores_gemma":[0.9993811,0.0003662343,0.00003519075,0.00008953128,0.00003299832,0.00009494587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06162621,0.00006764048,0.8379154,0.00001264865,0.0002987162,0.0001475161,0.00181905,0.0001524553,0.08760021,0.0003872919,0.00006459481,0.009908297],"study_design_scores_gemma":[0.01666015,0.002729294,0.9729788,0.00003727277,0.000125769,0.0004309636,0.00004252189,0.0001696426,0.00111133,0.001005831,0.004551209,0.0001571564],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.937677,0.0006913698,0.0005602331,0.06035156,0.00004884582,0.0003215485,0.00003962458,0.00002570406,0.0002841292],"genre_scores_gemma":[0.9928324,0.0001428757,0.000225999,0.006386777,0.00008485976,0.00005403122,0.000004418189,0.0000148468,0.0002537601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1350635,"threshold_uncertainty_score":0.3567375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197156036507098,"score_gpt":0.2560421079920506,"score_spread":0.2440705476269796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}