{"id":"W2296782701","doi":"10.1021/acs.jmedchem.5b01549","title":"Discovery and Structure–Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Mitacs; Canada Research Chairs; Heart and Stroke Foundation of Canada; Merck","keywords":"Chemistry; Fragment (logic); Structure–activity relationship; Stereochemistry; Biological activity; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158701,0.0002283518,0.0002361135,0.0002067481,0.0001297651,0.0002155908,0.0002055861,0.0002585351,0.001069654],"category_scores_gemma":[0.00015925,0.0000865641,0.0002559354,0.0001341802,0.0002152484,0.000220603,0.0001749889,0.000511726,0.0002152265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505116,"about_ca_system_score_gemma":0.0002139965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003534108,"about_ca_topic_score_gemma":0.0004374928,"domain_scores_codex":[0.9999586,0.000007614842,0.000002785302,0.000007246369,0.000008763124,0.00001493605],"domain_scores_gemma":[0.999933,0.00001366307,0.00001689984,0.00000500589,0.000008154712,0.00002324713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008827328,0.0002206352,0.0003157284,0.0000647655,0.0000222328,0.0002711154,0.00002705728,0.0006561808,0.991812,0.000253377,0.00006822177,0.005406015],"study_design_scores_gemma":[0.0004037714,0.006618507,0.005853909,0.00001726787,0.0001005434,0.001007256,0.00004872166,0.002182448,0.9755301,0.0002453516,0.007964227,0.00002792654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936332,0.002001909,0.002329933,0.0001175182,0.00002410299,0.00007245723,0.0002919347,0.00002176318,0.00150732],"genre_scores_gemma":[0.9946621,0.001132777,0.002549718,0.00007549991,0.00001396282,0.00002389689,0.0005225614,0.000007172112,0.001012354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069654,"threshold_uncertainty_score":0.003578365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744236236020402,"score_gpt":0.2805605333610228,"score_spread":0.2631181710008187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}