{"id":"W2296940157","doi":"10.1093/annonc/mdu331.40","title":"Phase Ii, Multicenter, Open-Label, Proof of Concept Study of Tasquinimod in Patients with Advanced Hepatocellular (Hcc), Ovarian (Oc), Renal Cell (Rcc) and Gastric (Gc) Carcinomas","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Clear cell; Hepatocellular carcinoma; Open label; Proof of concept; Oncology; Gastroenterology; Renal cell carcinoma; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001564787,0.001505994,0.002513067,0.0003144451,0.0004681797,0.001241965,0.0007622027,0.00110144,0.003395723],"category_scores_gemma":[0.0007506115,0.0006875015,0.001498094,0.0003186508,0.001469864,0.001238665,0.0003135468,0.003567399,0.0007190788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008359692,"about_ca_system_score_gemma":0.001318956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008250704,"about_ca_topic_score_gemma":0.001929586,"domain_scores_codex":[0.9997001,0.0001054394,0.00001179937,0.00007434794,0.00002476777,0.00008360815],"domain_scores_gemma":[0.9994059,0.00008855645,0.00007605376,0.00006232376,0.00005509534,0.000312234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8305385,0.06473492,0.005194653,0.0009115534,0.001863781,0.000184134,0.0004157034,0.002392575,0.03927803,0.0004821081,0.003926144,0.05007786],"study_design_scores_gemma":[0.6076503,0.378456,0.007041777,0.00002660434,0.0005392199,0.0001617337,0.0001634599,0.001298192,0.002182551,0.0002960084,0.002145552,0.00003852961],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994603,0.001284723,0.0006555101,0.000391155,0.0002158076,0.001235844,0.0006088484,0.00006893881,0.0009362557],"genre_scores_gemma":[0.9913979,0.001251359,0.001452748,0.000847864,0.0001981154,0.001356801,0.001211613,0.0000270862,0.002256583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003395723,"threshold_uncertainty_score":0.01135987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03769151185533347,"score_gpt":0.3160010859164408,"score_spread":0.2783095740611073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}