{"id":"W2297352149","doi":"10.1242/jcs.180737","title":"Ca2+ is a key factor in α-synuclein-induced neurotoxicity","year":2016,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; University College London; University College London Hospitals NHS Foundation Trust; Parkinson's UK; Leverhulme Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Academy of Medical Sciences; Wellcome Trust; University of Dundee","keywords":"Biology; Neurotoxicity; Cell biology; Intracellular; Extracellular; Programmed cell death; Biophysics; Alpha-synuclein; Membrane; Monomer; Ion channel; Biochemistry; Chemistry; Parkinson's disease; Toxicity; Disease; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002778749,0.00009296012,0.0002022652,0.0002319153,0.00005378754,0.00002284191,0.0001971026,0.00003025356,0.0002215203],"category_scores_gemma":[0.0001215604,0.00005055925,0.00008772484,0.0003322606,0.0000745386,0.0002961891,0.00003617394,0.00009970257,0.00004655248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001748708,"about_ca_system_score_gemma":0.0004568834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001294892,"about_ca_topic_score_gemma":0.000003047088,"domain_scores_codex":[0.9986926,0.00002138657,0.000249803,0.0001721589,0.0006093343,0.0002547623],"domain_scores_gemma":[0.9991212,0.00003349123,0.0001926661,0.0001622185,0.00013704,0.0003533131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008069175,0.0002741962,0.02087529,0.000006586575,0.000005271295,0.0003832116,0.0001735358,1.645492e-7,0.9730633,0.00001512944,0.00006661397,0.005055935],"study_design_scores_gemma":[0.002110457,0.000581154,0.2942224,0.0001138583,0.00002071766,0.00008833248,0.0000213547,0.0000313835,0.7002352,0.0001617038,0.002342593,0.0000707689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972367,0.00003846771,0.00008667422,0.001010859,0.0001971456,0.0001158803,0.000004398149,0.000005044034,0.001304838],"genre_scores_gemma":[0.9987014,0.00004175291,0.0005289786,0.0003983601,0.00005072393,0.000001203416,2.447904e-8,0.0000061977,0.0002713747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2733471,"threshold_uncertainty_score":0.2425492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296742903291374,"score_gpt":0.2862429581445047,"score_spread":0.2565686678153674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}