{"id":"W2297352149","doi":"10.1242/jcs.180737","title":"Ca2+ is a key factor in α-synuclein-induced neurotoxicity","year":2016,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; University College London; University College London Hospitals NHS Foundation Trust; Parkinson's UK; Leverhulme Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Academy of Medical Sciences; Wellcome Trust; University of Dundee","keywords":"Biology; Neurotoxicity; Cell biology; Intracellular; Extracellular; Programmed cell death; Biophysics; Alpha-synuclein; Membrane; Monomer; Ion channel; Biochemistry; Chemistry; Parkinson's disease; Toxicity; Disease; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002445695,0.0005861927,0.0006868692,0.0003834513,0.0004856481,0.0008184127,0.0003593903,0.001356822,0.0006821547],"category_scores_gemma":[0.0003365611,0.0002436246,0.0003245578,0.0002920473,0.0004539748,0.0007030151,0.0004842255,0.0006398878,0.0003426781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006353502,"about_ca_system_score_gemma":0.0003573897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006465967,"about_ca_topic_score_gemma":0.0007327303,"domain_scores_codex":[0.9997286,0.00003912328,0.00003794338,0.00006691024,0.00007376718,0.00005370854],"domain_scores_gemma":[0.9997939,0.00003270059,0.00006882486,0.00001548083,0.00004663118,0.00004257727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009126873,0.0001074914,0.001613538,0.0005711252,0.00004540182,0.001726012,0.00008505693,0.0004352073,0.9858717,0.001098428,0.0008339925,0.006699407],"study_design_scores_gemma":[0.0003927909,0.00195667,0.07299468,0.0002824522,0.0002757884,0.006629459,0.000456998,0.006004988,0.8609378,0.01275053,0.03723148,0.00008635863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8443894,0.1337175,0.007552761,0.003206933,0.0005856624,0.0002212195,0.0006954376,0.0005402411,0.009090884],"genre_scores_gemma":[0.976121,0.01949169,0.001600855,0.0002821016,0.0001656788,0.0000739618,0.0002130942,0.00001850393,0.002033129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356822,"threshold_uncertainty_score":0.004609823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296742903291374,"score_gpt":0.2862429581445047,"score_spread":0.2565686678153674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}