{"id":"W2297829040","doi":"10.3899/jrheum.150738","title":"Path Analysis Identifies Receptor Activator of Nuclear Factor-κB Ligand, Osteoprotegerin, and Sclerostin as Potential Mediators of the Tophus-bone Erosion Relationship in Gout","year":2016,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sclerostin; Osteoprotegerin; RANKL; Medicine; Internal medicine; RANK Ligand; Gout; Tophus; Bone erosion; Endocrinology; Receptor; Activator (genetics); Uric acid; Arthritis; Biology; Hyperuricemia; Cell biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090325,0.0007742495,0.0004190375,0.0008642042,0.0002607181,0.0006915623,0.0003108757,0.0003031156,0.005571539],"category_scores_gemma":[0.003835006,0.0002464203,0.0009299305,0.0007715366,0.0004388063,0.000462726,0.0006418493,0.0006494236,0.000257138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004250542,"about_ca_system_score_gemma":0.001560275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002961863,"about_ca_topic_score_gemma":0.002625502,"domain_scores_codex":[0.9994977,0.0002983831,0.00001751461,0.00006129157,0.00005490202,0.00007020515],"domain_scores_gemma":[0.9976546,0.001268082,0.0006329734,0.00006598295,0.0001586945,0.0002197735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001673878,0.0004496315,0.9508815,0.0001814272,0.0007774346,0.0004499135,0.0002703175,0.005784981,0.00329997,0.001525284,0.0007718761,0.03393386],"study_design_scores_gemma":[0.0002075892,0.001629918,0.9428341,0.00009710609,0.0005259703,0.0009992191,0.0004900084,0.04685806,0.0009134352,0.003996288,0.001410258,0.00003805828],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914963,0.0007275872,0.005437149,0.000585895,0.00001809979,0.00009728326,0.000683683,0.00005563922,0.0008982901],"genre_scores_gemma":[0.992309,0.0004614667,0.006153889,0.00004442139,0.00001172993,0.00007412477,0.0004054203,0.000006822735,0.0005330951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005571539,"threshold_uncertainty_score":0.01863867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046560483474862,"score_gpt":0.2371436835246959,"score_spread":0.2266780786899472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}