{"id":"W2297955304","doi":"10.1021/acs.jmedchem.5b00841","title":"Synthesis and Characterization in Vitro and in Vivo of (<scp>l</scp>)-(Trimethylsilyl)alanine Containing Neurotensin Analogues","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Neurotensin; Chemistry; Alanine; Receptor; In vivo; In vitro; Peptide; Stereochemistry; Amino acid; Biological activity; Neuropeptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496903,0.0002911884,0.0001804126,0.00009919245,0.00007398736,0.0001084011,0.0001217165,0.0001633553,0.0009882513],"category_scores_gemma":[0.0001095956,0.00008189971,0.0001456797,0.00007171815,0.0001092114,0.000137277,0.00006241869,0.0002893983,0.0003218741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298576,"about_ca_system_score_gemma":0.0001246591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002178221,"about_ca_topic_score_gemma":0.0003683383,"domain_scores_codex":[0.9999418,0.00001447993,0.000005687417,0.00001076201,0.00001306792,0.00001403948],"domain_scores_gemma":[0.9998933,0.00001994803,0.00004128731,0.000008852831,0.00001365997,0.00002294836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001102029,0.00001980238,0.00003362124,0.00001673007,0.000001909795,0.00002031254,0.000003701217,0.00006222611,0.9991893,0.00001271077,0.000006921421,0.000522643],"study_design_scores_gemma":[0.00002676567,0.001580477,0.00124259,0.00000225694,0.00001313081,0.0001580131,0.000006846235,0.0003093194,0.9958057,0.000008057025,0.0008442198,0.000002506649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939623,0.001081059,0.003713342,0.00003313645,0.0000180741,0.00005661362,0.0002886748,0.0000276333,0.0008191235],"genre_scores_gemma":[0.9892671,0.001375936,0.00601197,0.00005225933,0.00002368288,0.00007013936,0.001039551,0.00001774814,0.002141636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009882513,"threshold_uncertainty_score":0.003306031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03121827191465291,"score_gpt":0.2561537266422181,"score_spread":0.2249354547275652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}