{"id":"W2298019422","doi":"10.1007/s00018-001-8398-y","title":"Human Genome and Diseases: A new series of reviews in CMLS Werner Syndrome: genetic and molecular basis of a premature aging disorder","year":2001,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec; Université Laval","funders":"","keywords":"Genetics; Biology; Genome instability; Werner syndrome; Exonuclease; Helicase; Subfamily; Gene; DNA; Premature aging; Genome; DNA damage; DNA polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009960908,0.001849194,0.002709434,0.003322235,0.0004501544,0.001399597,0.00125658,0.002190966,0.003117878],"category_scores_gemma":[0.001804915,0.000399436,0.0007581291,0.004646131,0.0008153671,0.002885534,0.001203888,0.003291305,0.002306342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000713353,"about_ca_system_score_gemma":0.001001138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117497,"about_ca_topic_score_gemma":0.002933907,"domain_scores_codex":[0.9995735,0.00008736828,0.00007226333,0.00006536135,0.0001700338,0.00003147649],"domain_scores_gemma":[0.9987,0.0006071226,0.0001207946,0.00003433751,0.0003451768,0.0001924971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001380671,0.00008721922,0.0002401542,0.008465228,0.0001449181,0.0006028777,0.0001086787,0.0004726363,0.002136101,0.002190063,0.3481109,0.6373032],"study_design_scores_gemma":[0.00002841406,0.00006107782,0.0005049414,0.001771033,0.0001154894,0.001701704,0.00006773599,0.00008346747,0.0001808715,0.001364743,0.9940969,0.00002350569],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007138941,0.9940112,0.0004161856,0.001032253,0.00376549,0.000007729425,0.00002000266,0.0000210017,0.0006546626],"genre_scores_gemma":[0.0003739337,0.990387,0.0007805828,0.002201342,0.00481468,0.00001410564,0.00006668257,0.000007172922,0.001354586],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003322235,"threshold_uncertainty_score":0.0104304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517395155086646,"score_gpt":0.2714227741517101,"score_spread":0.2562488226008436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}