{"id":"W2298127727","doi":"10.1007/s00125-016-3916-5","title":"PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes","year":2016,"lang":"en","type":"article","venue":"Diabetologia","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Endocrinology; Polyuria; Internal medicine; Streptozotocin; Reabsorption; Aquaporin 2; Vasopressin; Urine osmolality; Kidney; Medicine; Chemistry; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386149,0.0001294645,0.0001945371,0.00008692327,0.00002364989,0.000007999744,0.00005351666,0.0001798794,0.000006314137],"category_scores_gemma":[0.00006211278,0.00008586913,0.00002484169,0.00005506951,0.00006497962,0.000009395257,0.0000482321,0.00003615621,0.000002183088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000108243,"about_ca_system_score_gemma":0.00002324683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006476867,"about_ca_topic_score_gemma":0.000005881333,"domain_scores_codex":[0.9991822,0.00003168472,0.000222104,0.0002778045,0.00005939055,0.0002268251],"domain_scores_gemma":[0.9996423,0.000007493235,0.00004546254,0.0001419314,0.00007710994,0.00008577219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007975056,0.00002557326,0.1030219,0.00002808145,0.00001589735,6.044758e-8,0.00006079208,0.000005026848,0.8950865,0.00002620856,0.000149144,0.00150111],"study_design_scores_gemma":[0.0006792097,0.0001835653,0.02201199,0.00005640525,0.000007117572,7.815984e-8,0.000007727602,0.00006335416,0.9765159,0.0002125012,0.0001314197,0.000130723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987552,0.00006858818,0.0002207948,0.0005368819,0.00004564372,0.0002588565,0.00009608228,0.00001004714,0.000007882404],"genre_scores_gemma":[0.9992965,0.00005420092,0.0001114645,0.000179556,0.0000224539,0.0000408015,0.00009266731,0.00001248279,0.000189892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08142942,"threshold_uncertainty_score":0.3501642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007988306077873803,"score_gpt":0.2153033000287549,"score_spread":0.2073149939508811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}