{"id":"W2298143626","doi":"10.1038/srep22087","title":"Demethylation of c-MYB binding site mediates upregulation of Bdnf IV in cocaine-conditioned place preference","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Tianjin Municipal Education Commission; College of Engineering, Michigan State University; National Natural Science Foundation of China; Michigan State University","keywords":"Conditioned place preference; Nucleus accumbens; Demethylation; Brain-derived neurotrophic factor; Downregulation and upregulation; Binding site; Chemistry; Pharmacology; Biology; Neuroscience; Gene expression; Addiction; Biochemistry; DNA methylation; Neurotrophic factors; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007014556,0.0001980044,0.0001956687,0.000101524,0.0001192433,0.0001096832,0.0001127176,0.0001586922,0.0009495668],"category_scores_gemma":[0.00009683992,0.0001348253,0.0001967688,0.00004900813,0.0002167118,0.0001053346,0.0001541949,0.0004991002,0.0001925224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087268,"about_ca_system_score_gemma":0.0001555193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009686135,"about_ca_topic_score_gemma":0.001604892,"domain_scores_codex":[0.9999321,0.00000818176,0.000004588492,0.0000181164,0.00001264133,0.00002448201],"domain_scores_gemma":[0.9999144,0.000008396767,0.00003145229,0.000007000375,0.0000084884,0.00003021973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007659457,0.000005762975,0.0001548881,0.00000594501,0.000001455832,0.00001471041,0.000005724358,0.000004992993,0.9995078,0.00001461476,0.000004394911,0.000203155],"study_design_scores_gemma":[0.00001931271,0.0002739574,0.0368723,0.000006700326,0.0000152067,0.0002344558,0.00003475071,0.000402098,0.961482,0.00005160566,0.0006032445,0.000004333761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980083,0.0005229665,0.0009411777,0.00004391677,0.000009802213,0.000007438621,0.00008912994,0.00001463439,0.0003626889],"genre_scores_gemma":[0.9979826,0.0003113553,0.0007589604,0.00002845107,0.000004372202,0.00001565665,0.000140531,0.000007302743,0.0007506654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009686135,"threshold_uncertainty_score":0.00317663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04470467819637014,"score_gpt":0.2789999193202978,"score_spread":0.2342952411239276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}