{"id":"W2298325430","doi":"10.1530/erc-15-0105","title":"Estrogen regulates luminal progenitor cell differentiation through H19 gene expression","year":2015,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Cancer Society Research Institute; Cure Brain Cancer Foundation; CancerCare Manitoba Foundation; University of Manitoba; Manitoba Health Research Council","keywords":"Progenitor cell; Estrogen receptor; Estrogen; Matrigel; Biology; Progenitor; Estrogen receptor alpha; Signal transduction; Cell biology; Estrogen receptor beta; Cancer research; Cellular differentiation; Endocrinology; Internal medicine; Stem cell; Breast cancer; Cancer; Angiogenesis; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000568393,0.0001308896,0.0001015503,0.0001439408,0.00009593549,0.0002003809,0.00008674199,0.00009923824,0.0009422855],"category_scores_gemma":[0.00005785322,0.00008549866,0.0001138891,0.00008879935,0.0001044204,0.00009779342,0.0001150925,0.0002257913,0.0003359844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001445158,"about_ca_system_score_gemma":0.0001469935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520092,"about_ca_topic_score_gemma":0.0006928642,"domain_scores_codex":[0.9999628,0.000005565495,0.000002384644,0.000006664087,0.0000109145,0.00001160045],"domain_scores_gemma":[0.9999657,0.000006473621,0.000008390016,0.000002459454,0.000005095052,0.00001189401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001044783,0.00002010811,0.0007200472,0.00001969382,0.000002615553,0.00006931608,0.00001637404,0.00003552665,0.9960228,0.0001919408,0.00007177544,0.002725288],"study_design_scores_gemma":[0.00002711484,0.0002651089,0.03003094,0.000008819688,0.00001821894,0.000259963,0.00007776778,0.0009817265,0.9591106,0.0001756429,0.009039927,0.000004181307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990998,0.002578762,0.002610153,0.0001160787,0.00002053085,0.00002097407,0.0003636129,0.00006223706,0.003229648],"genre_scores_gemma":[0.9885436,0.002982114,0.002046481,0.00007915636,0.00001884913,0.00002101557,0.0006429615,0.0000222053,0.005643601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009422855,"threshold_uncertainty_score":0.003152251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011903864252158,"score_gpt":0.2596078442966456,"score_spread":0.249488805654124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}