{"id":"W2298325430","doi":"10.1530/erc-15-0105","title":"Estrogen regulates luminal progenitor cell differentiation through H19 gene expression","year":2015,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Cancer Society Research Institute; Cure Brain Cancer Foundation; CancerCare Manitoba Foundation; University of Manitoba; Manitoba Health Research Council","keywords":"Progenitor cell; Estrogen receptor; Estrogen; Matrigel; Biology; Progenitor; Estrogen receptor alpha; Signal transduction; Cell biology; Estrogen receptor beta; Cancer research; Cellular differentiation; Endocrinology; Internal medicine; Stem cell; Breast cancer; Cancer; Angiogenesis; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007548214,0.0002778501,0.0002045872,0.00004176537,0.00009850847,0.00002792897,0.0001886484,0.0002479385,0.00004869871],"category_scores_gemma":[0.00002881898,0.0002347581,0.0001409247,0.0001522155,0.00006465812,0.00001597313,0.0001278685,0.0002408812,0.00005900714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000065625,"about_ca_system_score_gemma":0.0001475059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006311025,"about_ca_topic_score_gemma":0.000002195854,"domain_scores_codex":[0.9984493,0.0001056581,0.0002945705,0.0004785819,0.0002517616,0.0004201876],"domain_scores_gemma":[0.999143,0.00000759145,0.0001591082,0.000370405,0.0001254172,0.0001944947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002015965,0.0001205911,0.004135855,0.00002115421,0.0001265103,0.00002844145,0.0001194544,0.0004905461,0.9862433,0.00003730386,0.007752978,0.0007222481],"study_design_scores_gemma":[0.001799992,0.0003098166,0.0002366638,0.0000337739,0.00009546662,0.00008087524,0.00004374943,0.0001163482,0.9757624,0.000120766,0.02110709,0.0002930112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725699,0.02448406,0.0001278229,0.000134244,0.0008031071,0.0003564054,0.00001695678,0.00007035436,0.001437114],"genre_scores_gemma":[0.9924107,0.001337634,0.0009771347,0.000044382,0.0006710044,0.0001219462,0.0003882563,0.00006448928,0.003984442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02314642,"threshold_uncertainty_score":0.9573156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011903864252158,"score_gpt":0.2596078442966456,"score_spread":0.249488805654124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}