{"id":"W2298423717","doi":"10.1002/jcp.25383","title":"Kynurenine Modulates MMP‐1 and Type‐I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; California HIV/AIDS Research Program","keywords":"Aryl hydrocarbon receptor; Chemistry; Fibrosis; Extracellular matrix; Kynurenine; Cell biology; Receptor; Type I collagen; Biochemistry; Internal medicine; Endocrinology; Biology; Tryptophan; Medicine; Transcription factor; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009699225,0.0001162835,0.000362494,0.0001588733,0.00002854944,0.000003011354,0.00006174348,0.000153317,0.0001242417],"category_scores_gemma":[0.0001260659,0.00007216661,0.00006114775,0.00009262693,0.00009168372,0.000140594,0.00003209936,0.0001048726,0.00001178464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003018931,"about_ca_system_score_gemma":0.00006005091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001585099,"about_ca_topic_score_gemma":3.754334e-7,"domain_scores_codex":[0.9991643,0.00009236212,0.000331066,0.0001365758,0.0001092375,0.0001664771],"domain_scores_gemma":[0.9993212,0.0001331065,0.0002339408,0.0001144228,0.00009100575,0.0001062774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001561196,0.0001235367,0.009566825,0.00003919944,0.00003812814,0.00003638136,0.00006192274,0.000009117452,0.986303,0.00001007188,0.001537487,0.0007130799],"study_design_scores_gemma":[0.002337762,0.000373631,0.1227995,0.0003824636,0.00003430468,0.0001326249,0.00001869263,0.0001423217,0.8716044,0.001578488,0.0005013917,0.00009436774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979892,0.0005742009,0.0003755371,0.0007294036,0.0001663739,0.00009264845,8.358098e-7,0.000007796068,0.00006398762],"genre_scores_gemma":[0.9992391,0.0001314034,0.0001796305,0.000119369,0.0001999225,0.000001672501,0.000007336141,0.00001230146,0.0001092181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1146986,"threshold_uncertainty_score":0.2942869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007029166501369989,"score_gpt":0.2280050966594075,"score_spread":0.2209759301580375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}