{"id":"W2298687552","doi":"10.2174/1874467209666160112125631","title":"Interconnection of Estrogen/Testosterone Metabolism and Mevalonate Pathway in Breast and Prostate Cancers","year":2016,"lang":"en","type":"review","venue":"Current Molecular Pharmacology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Mevalonate pathway; Internal medicine; Endocrinology; Biology; Aromatase; Prostate cancer; Cancer research; Cholesterol; Lipid metabolism; Testosterone (patch); Hormone; Cancer; Breast cancer; Medicine; Reductase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004454525,0.0007064992,0.001354494,0.001345276,0.0002105776,0.0009702394,0.0008467633,0.0008541755,0.002795916],"category_scores_gemma":[0.0003322189,0.0002699248,0.0004178452,0.001588222,0.0003882916,0.0009847798,0.0007199734,0.001569065,0.001456166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005093194,"about_ca_system_score_gemma":0.001145248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039797,"about_ca_topic_score_gemma":0.002153459,"domain_scores_codex":[0.999879,0.00002006757,0.00001773682,0.00002380099,0.00004293344,0.00001644292],"domain_scores_gemma":[0.9998754,0.000040571,0.0000247751,0.000004778456,0.00003740414,0.00001695438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002441073,0.00008592893,0.0004090169,0.01630748,0.0001644669,0.0004498135,0.00005083009,0.0004644913,0.005300438,0.004307653,0.02100559,0.9512103],"study_design_scores_gemma":[0.0000588039,0.000159015,0.001621328,0.0025529,0.0003284153,0.001741343,0.00008268515,0.0001673596,0.001415403,0.003190543,0.9886516,0.00003049345],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001347155,0.998929,0.0001076617,0.0002118806,0.0001058877,0.000002774516,0.00001694706,0.000005783482,0.0004853421],"genre_scores_gemma":[0.0008110078,0.9984382,0.0001562105,0.00012081,0.0001211328,0.000003224399,0.00002899597,7.084321e-7,0.00031969],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002795916,"threshold_uncertainty_score":0.00935322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727112227493111,"score_gpt":0.3244498248701748,"score_spread":0.3071787025952437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}