{"id":"W2298711523","doi":"10.1021/acs.biochem.5b01136","title":"Chemical Biology in the Embryo: <i>In Situ</i> Imaging of Sulfur Biochemistry in Normal and Proteoglycan-Deficient Cartilage Matrix","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; National Institute of General Medical Sciences; Government of Saskatchewan; Western Economic Diversification Canada; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institutes of Health; Office of Science; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Argonne National Laboratory; U.S. Department of Energy; Heart and Stroke Foundation of Canada; National Research Council Canada; Canada Foundation for Innovation","keywords":"Cartilage; Sulfation; Extracellular matrix; Proteoglycan; Chemistry; Biochemistry; Chondrocyte; Zebrafish; Aggrecan; Cell biology; Perlecan; Keratan sulfate; Osteoarthritis; Biology; Anatomy; Articular cartilage; Pathology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670582,0.0003587876,0.0001594515,0.0002863549,0.0002731976,0.0002933068,0.0002827494,0.0005260317,0.002322365],"category_scores_gemma":[0.0001341882,0.0003007815,0.000215714,0.0001396969,0.0004165239,0.0004280346,0.0002578945,0.0006559351,0.0005005994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355857,"about_ca_system_score_gemma":0.0003061745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002316977,"about_ca_topic_score_gemma":0.002996291,"domain_scores_codex":[0.9999262,0.000008366195,0.000005409277,0.00002492281,0.00001953347,0.00001552954],"domain_scores_gemma":[0.9999133,0.00001895906,0.00002279354,0.00001069552,0.00001802445,0.00001621091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001849103,0.000002330606,0.00006261426,0.00001459241,9.180435e-7,0.00004951831,0.00001254335,0.00002283315,0.9992555,0.0001381539,0.00002113845,0.0004014177],"study_design_scores_gemma":[0.00001222606,0.00009850505,0.004099674,0.00001060512,0.00001010501,0.0005033975,0.00004585373,0.0009286346,0.9915352,0.0001455298,0.002602624,0.000007696595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9403803,0.003075991,0.04279056,0.000637776,0.0001799176,0.00008977552,0.0008456733,0.000434313,0.01156564],"genre_scores_gemma":[0.9316378,0.00256785,0.04543105,0.0003045426,0.00003895543,0.0001177983,0.0006484305,0.0002502761,0.01900318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002322365,"threshold_uncertainty_score":0.007769108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005895577092810116,"score_gpt":0.2427740486740765,"score_spread":0.2368784715812664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}