{"id":"W2298718405","doi":"10.1021/acs.biomac.5b00567","title":"The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Ministry of Science and Technology of the People's Republic of China; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"Chemistry; Peptide; Dimer; RNase P; Combinatorial chemistry; Protein–protein interaction; Proteolysis; Non-covalent interactions; Folding (DSP implementation); Hydrophobic effect; Proteolytic enzymes; Stereochemistry; Biophysics; Biochemistry; Hydrogen bond; Molecule; Organic chemistry; Enzyme; RNA; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746186,0.0001823031,0.0001610381,0.00008172387,0.0001180535,0.0002743205,0.0001046271,0.0001709533,0.0003377314],"category_scores_gemma":[0.0001331403,0.0001168022,0.0001001697,0.00008011978,0.0001961641,0.0002511621,0.0001644107,0.0003223609,0.0001099778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244815,"about_ca_system_score_gemma":0.00009539399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006603489,"about_ca_topic_score_gemma":0.0001461084,"domain_scores_codex":[0.9999039,0.00002297417,0.000008073604,0.00002227264,0.00002221342,0.00002057162],"domain_scores_gemma":[0.9999192,0.00002134545,0.00002794113,0.000007484124,0.000008251574,0.00001585945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003236777,0.000008830832,0.0001007481,0.00001538133,0.000002928104,0.00003623266,0.00001187694,0.0001433162,0.9986088,0.000142652,0.000009376833,0.000887435],"study_design_scores_gemma":[0.000005383687,0.00009944888,0.0005325631,0.000001781773,0.000004301654,0.0001244591,0.00001172866,0.00070087,0.9978264,0.0000666853,0.0006240787,0.000002419473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941901,0.0008456031,0.0042503,0.00004008196,0.000005113365,0.000008824071,0.0000203917,0.00001858425,0.0006210642],"genre_scores_gemma":[0.9977775,0.0002656371,0.001624585,0.00001834139,0.000002670094,0.000004507706,0.00002391302,0.000003595478,0.0002792274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003377314,"threshold_uncertainty_score":0.001129806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294099830183428,"score_gpt":0.2748292663331905,"score_spread":0.2618882680313563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}