{"id":"W2298802783","doi":"10.1186/s40425-016-0116-2","title":"Systemic versus local responses in melanoma patients treated with talimogene laherparepvec from a multi-institutional phase II study","year":2016,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"University of California, San Diego; U.S. Food and Drug Administration; Amgen","keywords":"Medicine; Oncolytic virus; Melanoma; Internal medicine; Oncology; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003050731,0.0001991157,0.000279914,0.0001207002,0.0001525742,0.00001509114,0.0002542693,0.00009491019,0.00008815523],"category_scores_gemma":[0.00003254934,0.000120298,0.0001159354,0.0001062389,0.0001396535,0.00001350421,0.00002753621,0.00008619888,0.000001066745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046915,"about_ca_system_score_gemma":0.000440311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002474182,"about_ca_topic_score_gemma":0.001515061,"domain_scores_codex":[0.9985898,0.0001723614,0.0003981426,0.0002699599,0.0003011243,0.0002686714],"domain_scores_gemma":[0.999084,0.00005035643,0.0002220929,0.0002658901,0.0003090581,0.00006860594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2181185,0.001380126,0.03285583,0.000005454401,0.0007220753,0.00001038168,0.0001508599,0.0001277488,0.6808147,4.533867e-7,0.00004556068,0.0657683],"study_design_scores_gemma":[0.1501964,0.08441024,0.01429173,0.0002661052,0.00006870022,0.00001720523,0.0002959118,0.00007647051,0.7465612,0.000005736855,0.00338871,0.000421548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926774,0.004855964,0.0011745,0.00005186888,0.0002038544,0.0006517135,0.0003751427,0.00000507726,0.000004472552],"genre_scores_gemma":[0.9985403,0.0006637297,0.0001294401,0.0000359147,0.00012262,0.000159054,0.00002736256,0.00003689903,0.0002846622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08303012,"threshold_uncertainty_score":0.4905611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02881937285232573,"score_gpt":0.3572661509682807,"score_spread":0.328446778115955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}