{"id":"W2298802783","doi":"10.1186/s40425-016-0116-2","title":"Systemic versus local responses in melanoma patients treated with talimogene laherparepvec from a multi-institutional phase II study","year":2016,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"University of California, San Diego; U.S. Food and Drug Administration; Amgen","keywords":"Medicine; Oncolytic virus; Melanoma; Internal medicine; Oncology; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001280991,0.0005174335,0.0009180646,0.0002334413,0.0002448831,0.0004243809,0.0002916238,0.0004144753,0.001449458],"category_scores_gemma":[0.0005201887,0.0002263034,0.0004591131,0.0002250497,0.000398047,0.0003264314,0.0002101003,0.00113885,0.0002143784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264081,"about_ca_system_score_gemma":0.0004213724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000219541,"about_ca_topic_score_gemma":0.0004533011,"domain_scores_codex":[0.999642,0.0001693447,0.00002137202,0.00006194321,0.00004269627,0.00006265581],"domain_scores_gemma":[0.9994018,0.0001377877,0.0001408986,0.00006947076,0.00003462031,0.000215347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3735938,0.07586423,0.09979652,0.000659052,0.001591815,0.0004852661,0.0004532941,0.003021291,0.3399124,0.0001429522,0.001760143,0.1027193],"study_design_scores_gemma":[0.04952855,0.7890071,0.1266216,0.00002514325,0.0006732255,0.0007076529,0.0001173735,0.001607188,0.02984587,0.00006129153,0.001779012,0.00002594153],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989875,0.000317187,0.0001315138,0.00002088196,0.000008406538,0.0001982913,0.0000956214,0.000009698851,0.0002309317],"genre_scores_gemma":[0.9983467,0.000208682,0.0002974765,0.00009531059,0.00004240565,0.0002859101,0.0004167153,0.00000464371,0.0003021731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449458,"threshold_uncertainty_score":0.006774604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02881937285232573,"score_gpt":0.3572661509682807,"score_spread":0.328446778115955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}