{"id":"W2298857745","doi":"10.1042/bj20151077","title":"TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors","year":2016,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Liver X receptor; Poly ADP ribose polymerase; Gene knockdown; Biology; Molecular biology; PARP1; RNA polymerase II; ADP-ribosylation; Polymerase; Cell biology; Transcription factor; Gene expression; Promoter; Nuclear receptor; Gene; Biochemistry; NAD+ kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003442153,0.0003824884,0.0005149753,0.0002332901,0.0002149588,0.00008836688,0.0001940756,0.0003113149,0.002710974],"category_scores_gemma":[0.0002472665,0.000259099,0.000211773,0.0002252078,0.0004055838,0.0003034879,0.00006634076,0.0005579144,0.0001872414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177004,"about_ca_system_score_gemma":0.0002258502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002605657,"about_ca_topic_score_gemma":4.440966e-7,"domain_scores_codex":[0.9976226,0.00009980599,0.0005825826,0.000516844,0.0005211031,0.0006570424],"domain_scores_gemma":[0.9980257,0.0002516047,0.0002783035,0.0003749562,0.0001835062,0.0008859946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009214196,0.0001980433,0.008157144,0.00002665615,0.0001604076,0.00009095548,0.000165316,4.469813e-8,0.9088733,0.00003377891,0.06143737,0.01993558],"study_design_scores_gemma":[0.004207936,0.0003655983,0.001569713,0.0005628031,0.00007277476,0.001743112,0.0001011817,0.000008201453,0.9519885,0.0003315402,0.03867907,0.0003696136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801445,0.009083467,0.0003333631,0.008524194,0.0005927318,0.0002388479,0.00004741799,0.0001141627,0.0009213276],"genre_scores_gemma":[0.9900532,0.003611369,0.001164963,0.001252093,0.002391936,0.00002232342,0.00001530978,0.00007364742,0.001415104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04311517,"threshold_uncertainty_score":0.9999861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565698221800723,"score_gpt":0.3006335318363137,"score_spread":0.2749765496183065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}