{"id":"W2298956820","doi":"10.1161/atvb.35.suppl_1.445","title":"Abstract 445: Beraprost, a Prostacyclin Analogue, Inhibits Human Vascular Smooth Muscle Cell Migration via Activation of Exchange Protein Activated by cAMP (Epac)","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gibson Energy (Canada)","funders":"","keywords":"Prostacyclin; Vascular smooth muscle; Cell biology; RHOA; Cyclic adenosine monophosphate; Cell migration; Protein kinase A; Chemistry; Forskolin; Internal medicine; Endocrinology; Signal transduction; Receptor; Cell; Medicine; Biology; Biochemistry; Kinase; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008057735,0.0003366938,0.0003255215,0.0001479083,0.0001536242,0.0001776215,0.000154603,0.000276786,0.006296677],"category_scores_gemma":[0.00008740451,0.00009682986,0.0001968617,0.00007433551,0.0002020046,0.0001348113,0.00009761054,0.0006703582,0.001268866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971514,"about_ca_system_score_gemma":0.0002023608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002631751,"about_ca_topic_score_gemma":0.0002276379,"domain_scores_codex":[0.9999307,0.00001159795,0.0000045924,0.00001540273,0.00001700825,0.00002052479],"domain_scores_gemma":[0.9999659,0.00001044803,0.000006878686,0.000003163446,0.00000393847,0.000009639894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009657578,0.0001117249,0.0001566607,0.0001676795,0.000007852082,0.0001299264,0.00000858606,0.00005114701,0.9926443,0.0001256876,0.0003968967,0.005233761],"study_design_scores_gemma":[0.0002025174,0.001988788,0.007416945,0.00001477231,0.00002856312,0.001060945,0.00001160096,0.0004407044,0.9833714,0.00007949644,0.005379509,0.000004668826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767104,0.007879481,0.0031613,0.0006936991,0.0003837624,0.0001053971,0.0008081879,0.0002889151,0.009968854],"genre_scores_gemma":[0.9813269,0.002200391,0.0022148,0.0002166415,0.0001451747,0.00006553937,0.001042433,0.0000226047,0.01276542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006296677,"threshold_uncertainty_score":0.02106446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03035632094596892,"score_gpt":0.2658439719587264,"score_spread":0.2354876510127575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}