{"id":"W2298956820","doi":"10.1161/atvb.35.suppl_1.445","title":"Abstract 445: Beraprost, a Prostacyclin Analogue, Inhibits Human Vascular Smooth Muscle Cell Migration via Activation of Exchange Protein Activated by cAMP (Epac)","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gibson Energy (Canada)","funders":"","keywords":"Prostacyclin; Vascular smooth muscle; Cell biology; RHOA; Cyclic adenosine monophosphate; Cell migration; Protein kinase A; Chemistry; Forskolin; Internal medicine; Endocrinology; Signal transduction; Receptor; Cell; Medicine; Biology; Biochemistry; Kinase; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005453305,0.0003882109,0.0004651195,0.0001003854,0.0001618029,0.00004415663,0.0002201607,0.0004438511,0.00003032827],"category_scores_gemma":[0.00008305883,0.0003701262,0.0002343395,0.0002152102,0.0002492919,0.00003456522,0.0001567434,0.0001531083,0.000005786162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004001271,"about_ca_system_score_gemma":0.00007546281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004041728,"about_ca_topic_score_gemma":0.00008786151,"domain_scores_codex":[0.997771,0.0002680697,0.0005312706,0.000786012,0.0002264451,0.0004171805],"domain_scores_gemma":[0.9985057,0.00001693005,0.0003697476,0.0006230093,0.0002487725,0.0002359034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001735918,0.0004450008,0.01081408,0.00008903192,0.0001438933,4.334757e-8,0.0003142203,0.00000899364,0.9870008,0.000009217995,0.0007890989,0.0003682637],"study_design_scores_gemma":[0.001762898,0.0008095935,0.1943726,0.00008622674,0.00006820088,9.135751e-8,0.0001119435,0.00002283166,0.7984698,0.00007293074,0.003813959,0.0004089551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973516,0.0003180403,0.001034978,0.0001107665,0.0000628845,0.0008918028,0.0001342193,0.00003965388,0.00005604915],"genre_scores_gemma":[0.9970861,0.0003265312,0.0003164498,0.0001849557,0.0001004889,0.0002111285,0.001709252,0.00005831701,0.000006743284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.188531,"threshold_uncertainty_score":0.9998751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03035632094596892,"score_gpt":0.2658439719587264,"score_spread":0.2354876510127575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}