{"id":"W2298967084","doi":"10.1016/j.virol.2016.02.014","title":"GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription","year":2016,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"Higher Education Discipline Innovation Project; National Natural Science Foundation of China","keywords":"Biology; Gene knockdown; Cell biology; Transcription (linguistics); DNA damage; Transcription factor; Gadd45; Cell cycle; Cell culture; Cell; Cell cycle checkpoint; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000175058,0.0001383694,0.0002495628,0.0000907542,0.00009334706,0.00000296651,0.000165916,0.0002723696,0.002474971],"category_scores_gemma":[0.00004849591,0.00008721029,0.00008494428,0.00008899596,0.0003594644,0.0001180918,0.00004238775,0.0001320515,0.004838151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004691214,"about_ca_system_score_gemma":0.00003381162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002616786,"about_ca_topic_score_gemma":0.000009031429,"domain_scores_codex":[0.9985921,0.0002815501,0.0002986655,0.0004250339,0.00004451237,0.0003581024],"domain_scores_gemma":[0.9991169,0.00009499036,0.0001092841,0.0005974725,0.00005730486,0.00002406376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005877017,0.0002568695,0.001468113,0.00001108823,0.00005949462,0.000006630284,0.000244424,3.440319e-7,0.9693979,0.001762753,0.01468421,0.01152045],"study_design_scores_gemma":[0.002487365,0.0005510779,0.01947751,0.00003053357,0.00001456875,0.00005196009,0.00002438721,2.654312e-7,0.7419804,0.0007551121,0.2345372,0.00008970843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814401,0.001699855,0.007554157,0.005144122,0.000223187,0.0007104794,0.000410531,0.00007917403,0.002738391],"genre_scores_gemma":[0.9943068,0.0004410997,0.0002698512,0.00004794046,0.00003417128,0.0001356456,0.0003828173,0.0000145292,0.00436715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2274176,"threshold_uncertainty_score":0.9984369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248544210735389,"score_gpt":0.2636717020525511,"score_spread":0.2388172809790123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}