{"id":"W2299075293","doi":"10.1194/jlr.m060954","title":"Metabolic engineering of Pichia pastoris to produce ricinoleic acid, a hydroxy fatty acid of industrial importance","year":2015,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Saskatchewan; Saskatchewan Research Council (Canada)","funders":"","keywords":"Ricinoleic acid; Claviceps purpurea; Fatty acid; Pichia pastoris; Biochemistry; Metabolic engineering; Chemistry; Biology; Castor oil; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294982,0.0007187702,0.0004145551,0.0003728729,0.0002046635,0.0003585517,0.0003529404,0.0002322462,0.0003880781],"category_scores_gemma":[0.0001220937,0.0002308582,0.0004561226,0.0005497592,0.0001435677,0.0002013644,0.0003752341,0.0005756936,0.0004039187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465161,"about_ca_system_score_gemma":0.0002790715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143157,"about_ca_topic_score_gemma":0.00146468,"domain_scores_codex":[0.9998023,0.00003201117,0.0000278207,0.00004256471,0.00005946152,0.00003587129],"domain_scores_gemma":[0.999954,0.000006093431,0.00001085953,0.000009881018,0.000007559281,0.00001168576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004272984,0.00003343821,0.0002273061,0.0000817979,0.000018644,0.0001193552,0.00002568091,0.0005879622,0.995482,0.0002247261,0.00007714747,0.003079268],"study_design_scores_gemma":[0.00003184939,0.0002435127,0.003139947,0.00001523266,0.00008399803,0.0003352032,0.00003742008,0.006170831,0.9738789,0.000143745,0.01590308,0.00001636325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453517,0.002357821,0.03947371,0.0003080413,0.0001835895,0.0003464736,0.002569629,0.0007667771,0.008642321],"genre_scores_gemma":[0.9383515,0.002401191,0.04626307,0.00009558225,0.00002444628,0.0003021568,0.004392243,0.0001088445,0.008060833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143157,"threshold_uncertainty_score":0.002846479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07409504721481759,"score_gpt":0.3207650813205166,"score_spread":0.246670034105699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}