{"id":"W2299075293","doi":"10.1194/jlr.m060954","title":"Metabolic engineering of Pichia pastoris to produce ricinoleic acid, a hydroxy fatty acid of industrial importance","year":2015,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Saskatchewan; Saskatchewan Research Council (Canada)","funders":"","keywords":"Ricinoleic acid; Claviceps purpurea; Fatty acid; Pichia pastoris; Biochemistry; Metabolic engineering; Chemistry; Biology; Castor oil; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003188052,0.0001554828,0.0004908364,0.0003690187,0.00003401629,0.00001623171,0.0005729013,0.0001894846,0.00001093638],"category_scores_gemma":[0.00248375,0.0001193085,0.0001610226,0.0005737318,0.00007810591,0.00001666248,0.000218313,0.000406745,0.00000410695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002471417,"about_ca_system_score_gemma":0.0005935808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001392031,"about_ca_topic_score_gemma":0.00000465155,"domain_scores_codex":[0.9975325,0.0002056255,0.0007361022,0.0002317335,0.0009079272,0.0003861066],"domain_scores_gemma":[0.9977664,0.00003447251,0.0003514312,0.0004372622,0.001072995,0.000337376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004536702,0.0001511789,0.01117258,0.00003505408,0.0001288151,0.000003762346,0.0002263725,0.00005957419,0.9794117,0.00001229084,0.003531002,0.004813996],"study_design_scores_gemma":[0.0007639256,0.0005063953,0.003522882,0.00005745627,0.00002854866,0.00002218805,0.0001363671,0.000006361648,0.9216985,0.000004638943,0.07314549,0.0001072702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951185,0.003407142,0.0001807655,0.0002924578,0.0006728837,0.0001917279,0.00001405247,0.000002772807,0.0001197217],"genre_scores_gemma":[0.9931114,0.0002036889,0.00249724,0.00001666867,0.004048737,0.000005810886,0.000002825428,0.00002317006,0.00009050419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06961449,"threshold_uncertainty_score":0.4865257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07409504721481759,"score_gpt":0.3207650813205166,"score_spread":0.246670034105699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}