{"id":"W2299219969","doi":"10.1016/s2352-3026(15)00247-1","title":"Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study","year":2016,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":431,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Agence Nationale de la Recherche","keywords":"Medicine; Bromodomain; Internal medicine; Leukemia; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001073891,0.001172663,0.002122558,0.0003184164,0.0002498633,0.001069375,0.0007196711,0.0006839643,0.003123243],"category_scores_gemma":[0.0007167363,0.0003356519,0.001330373,0.00035046,0.0006325482,0.0006527306,0.0003327486,0.002428746,0.0006279189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009494102,"about_ca_system_score_gemma":0.000968034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021326,"about_ca_topic_score_gemma":0.002723695,"domain_scores_codex":[0.9997218,0.0001167821,0.00001602646,0.00003884092,0.00003302758,0.00007353363],"domain_scores_gemma":[0.9995531,0.0001026672,0.00008279167,0.00003686708,0.00002208891,0.0002024414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6754246,0.02521362,0.006932453,0.001903653,0.002744624,0.0002688764,0.0004302393,0.004133288,0.03792024,0.0006941698,0.004556573,0.2397776],"study_design_scores_gemma":[0.5850488,0.3723701,0.02898311,0.0001403132,0.001031721,0.0005606789,0.0001932679,0.001982612,0.003367344,0.0005956614,0.00566627,0.00006012106],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940888,0.003118577,0.0003777983,0.0003064436,0.0001045839,0.0004433442,0.0004454794,0.00007002897,0.001044977],"genre_scores_gemma":[0.9879329,0.004139465,0.0011611,0.0007793856,0.0001349956,0.0006927825,0.001798863,0.00002556345,0.003335082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123243,"threshold_uncertainty_score":0.01044834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162699876201042,"score_gpt":0.2695873245110347,"score_spread":0.2579603257490243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}