{"id":"W2299322249","doi":"10.1016/j.ebiom.2016.03.004","title":"HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection","year":2016,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Childhood Cancer Canada; Bundesministerium für Bildung und Forschung; Friedrich-Alexander-Universität Erlangen-Nürnberg; European Commission; Deutsche Forschungsgemeinschaft; Comprehensive Cancer Center, City of Hope","keywords":"Immune system; Pathogenesis; Immunology; Population; Biology; CD14; Inflammation; Extracellular; Viral replication; Peripheral blood mononuclear cell; Virology; Medicine; Cell biology; Virus; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000241511,0.0002443439,0.0002242438,0.0005747117,0.0002037428,0.0005661786,0.0001212796,0.0003320276,0.001292646],"category_scores_gemma":[0.0003077953,0.0001917367,0.0001635436,0.0002612366,0.0003368881,0.0003950436,0.000374135,0.000459774,0.000235175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629695,"about_ca_system_score_gemma":0.0001258827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001605899,"about_ca_topic_score_gemma":0.0001198223,"domain_scores_codex":[0.9998634,0.0000231267,0.00002073499,0.00002701123,0.00002534056,0.00004031361],"domain_scores_gemma":[0.9997748,0.00003449781,0.00009056611,0.00001852069,0.00003125944,0.00005048398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001951327,0.0001201022,0.1093108,0.0002415396,0.00008431547,0.00224416,0.0003033043,0.0001285029,0.8706457,0.0006423666,0.0002174049,0.01411045],"study_design_scores_gemma":[0.00007059274,0.0007607108,0.751433,0.00006528549,0.0001283461,0.01491145,0.0005510303,0.001252539,0.2253363,0.001232067,0.004237423,0.00002129959],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956867,0.003132015,0.0006667377,0.00003099142,0.000009449685,0.00001018103,0.0001106818,0.0000154598,0.0003376388],"genre_scores_gemma":[0.9982088,0.0007108357,0.0004338577,0.0000135173,0.00001407283,0.00001445111,0.0001590729,0.000004384095,0.0004410002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292646,"threshold_uncertainty_score":0.004324317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006147393711476376,"score_gpt":0.2166719453351949,"score_spread":0.2105245516237185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}