{"id":"W2299666588","doi":"10.1007/s13318-016-0322-9","title":"Pharmacokinetic Time Course Scaling of a Subcutaneously Administered Pegylated Peptide Conjugate for a First-in-Human Investigation","year":2016,"lang":"en","type":"article","venue":"European Journal of Drug Metabolism and Pharmacokinetics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Pharmacokinetics; Human physiology; Conjugate; Peptide; Clinical chemistry; Pharmacology; Medicine; PEGylation; Medical physics; Chemistry; Internal medicine; Biochemistry; Mathematics; Polyethylene glycol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002297302,0.0004028281,0.0007067563,0.0003148415,0.0001597663,0.00002303145,0.000499159,0.00007952832,0.0004357836],"category_scores_gemma":[0.0001262829,0.0003234823,0.0002051616,0.0002419339,0.000513309,0.0002729555,0.00009073759,0.0006026085,0.00001831109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003385496,"about_ca_system_score_gemma":0.00008907315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002113009,"about_ca_topic_score_gemma":0.000001741999,"domain_scores_codex":[0.9959657,0.001241068,0.001603614,0.0003399397,0.0003244688,0.0005252105],"domain_scores_gemma":[0.9970906,0.000779223,0.001075395,0.0001795197,0.0004428339,0.0004324442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002675289,0.0005160019,0.001901381,0.0003538697,0.0005907838,0.000515776,0.002944704,0.002481022,0.9510427,0.000224487,0.003102193,0.03365183],"study_design_scores_gemma":[0.05882603,0.001208879,0.009382121,0.001202981,0.004613956,0.0008919142,0.0003226876,0.009630946,0.6484055,0.001320505,0.2625653,0.001629147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911671,0.003779974,0.00126757,0.001372293,0.001027352,0.0006168941,0.0002508113,0.00003088811,0.0004871394],"genre_scores_gemma":[0.9935241,0.003149894,0.001342035,0.0006858806,0.0005342104,0.000007697024,0.00001207944,0.00008734611,0.0006567905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3026372,"threshold_uncertainty_score":0.9999217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05078384283950307,"score_gpt":0.3618909323249342,"score_spread":0.3111070894854312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}