{"id":"W2299936619","doi":"10.1101/gr.197566.115","title":"nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs","year":2016,"lang":"en","type":"article","venue":"Genome Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Montreal General Hospital","funders":"National Institute of General Medical Sciences; Uppsala Multidisciplinary Center for Advanced Computational Science; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Vetenskapsrådet; Science for Life Laboratory; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Cancerfonden; Cancerföreningen i Stockholm; Barncancerfonden; Terry Fox Research Institute; Swedish Foundation for International Cooperation in Research and Higher Education; Ministère de la Santé et des Services sociaux; Knut och Alice Wallenbergs Stiftelse; McGill University","keywords":"EIF4E; Biology; PI3K/AKT/mTOR pathway; Ribosome profiling; EIF4G; Five prime untranslated region; Initiation factor; Untranslated region; Cell biology; EIF4A1; Messenger RNA; Eukaryotic initiation factor; Translation (biology); Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045484,0.0001729953,0.000227354,0.0001679119,0.0001325856,0.000241497,0.0001000156,0.0002593713,0.0005683822],"category_scores_gemma":[0.0002552524,0.0001664608,0.0002557478,0.0001043504,0.0001852658,0.0001721311,0.0001336631,0.0003006972,0.0002566732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774296,"about_ca_system_score_gemma":0.0001262023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003470014,"about_ca_topic_score_gemma":0.0005988625,"domain_scores_codex":[0.9998791,0.000009362839,0.000008743346,0.00004862478,0.00003521741,0.00001907116],"domain_scores_gemma":[0.999844,0.00004948986,0.00004948948,0.00001762155,0.00002243629,0.00001698314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005803728,0.000002875338,0.0001453567,0.00001580034,0.000002091508,0.00001288931,0.000007951066,0.00004904921,0.9991061,0.00006088361,0.00001546304,0.0005234172],"study_design_scores_gemma":[0.000005202304,0.0001235424,0.007647188,0.000006586642,0.00001717508,0.0001794809,0.00001959022,0.00152371,0.989099,0.00009314356,0.001275778,0.00000955981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986811,0.001324596,0.009421096,0.00006773131,0.0000395291,0.00002134462,0.0006334327,0.0001331362,0.001548112],"genre_scores_gemma":[0.9818626,0.0005283767,0.01497194,0.0001586015,0.00001820824,0.000081904,0.0009221351,0.00007952061,0.00137672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005683822,"threshold_uncertainty_score":0.002012908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07248892877031521,"score_gpt":0.3237459667710851,"score_spread":0.2512570380007699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}