{"id":"W2299938884","doi":"10.1016/j.celrep.2016.02.061","title":"Evasion of Cell Senescence Leads to Medulloblastoma Progression","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Université de Montréal; Montreal Clinical Research Institute; McGill University","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Senescence; Medulloblastoma; Evasion (ethics); Cell biology; Biology; Cellular senescence; Cell; Cancer research; Genetics; Gene; Phenotype; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007903932,0.0001584214,0.0001396928,0.0002280433,0.0001135608,0.0002201342,0.00007969239,0.0001371412,0.0005045937],"category_scores_gemma":[0.0000890681,0.0001013325,0.0001302105,0.0001044915,0.0001481209,0.0001450989,0.0001556509,0.0003500778,0.0001590298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495345,"about_ca_system_score_gemma":0.0001464321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092899,"about_ca_topic_score_gemma":0.001420564,"domain_scores_codex":[0.9999365,0.000009862882,0.000004731342,0.00001192732,0.00001865402,0.00001841022],"domain_scores_gemma":[0.9999141,0.00001232172,0.00002802949,0.00000945068,0.000006736374,0.00002935421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000621631,0.000009151009,0.000721572,0.00000959023,0.000002839975,0.00006251367,0.00001301404,0.00003421533,0.9983155,0.00008275014,0.00001284698,0.0006738153],"study_design_scores_gemma":[0.000009324861,0.0002968434,0.02774914,0.000004484506,0.00001426819,0.0005193498,0.00003837735,0.0006106637,0.9686438,0.0001428412,0.001966488,0.000004302228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977227,0.0007022539,0.0008473737,0.00002204041,0.00000581814,0.000007283301,0.0001222071,0.00003548066,0.0005348808],"genre_scores_gemma":[0.998122,0.000588321,0.0004559179,0.00000936491,0.000003932656,0.000005486493,0.0001325613,0.000006327381,0.0006760522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092899,"threshold_uncertainty_score":0.002173126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054230803348799,"score_gpt":0.2578340796304899,"score_spread":0.2472917715970019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}