{"id":"W2299938884","doi":"10.1016/j.celrep.2016.02.061","title":"Evasion of Cell Senescence Leads to Medulloblastoma Progression","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Université de Montréal; Montreal Clinical Research Institute; McGill University","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Senescence; Medulloblastoma; Evasion (ethics); Cell biology; Biology; Cellular senescence; Cell; Cancer research; Genetics; Gene; Phenotype; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002326941,0.0001346896,0.0001519002,0.00003764812,0.00004485863,0.000004397508,0.00009442813,0.0001018683,0.00001398003],"category_scores_gemma":[0.0001503092,0.00009036734,0.000071927,0.000076263,0.00006548021,0.000002208048,0.0001698277,0.00002899068,0.00001816882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001274376,"about_ca_system_score_gemma":0.00007792068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002369336,"about_ca_topic_score_gemma":0.000003181495,"domain_scores_codex":[0.9988489,0.00003245854,0.0003036901,0.0003985747,0.0002002925,0.0002160974],"domain_scores_gemma":[0.999081,0.00001326696,0.0001888048,0.0004629444,0.0001493256,0.0001047129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003035443,0.00006423645,0.01368744,0.00004084611,0.000004244838,0.00006114033,0.00004535211,0.000004365364,0.9811268,5.367984e-7,0.001730177,0.003204492],"study_design_scores_gemma":[0.0001325074,0.0003190365,0.001573647,0.0001024984,0.000008362326,0.00002948356,0.00001756682,5.44081e-7,0.9843099,0.000008887384,0.01336379,0.0001338165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949829,0.000451378,0.001638728,0.00007516163,0.0002489369,0.0001968509,0.000002831919,0.00001647646,0.002386733],"genre_scores_gemma":[0.9960653,0.00005738264,0.001200719,0.00004468223,0.00009779041,0.00001854966,0.000005170158,0.00002016624,0.002490241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0121138,"threshold_uncertainty_score":0.3685073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054230803348799,"score_gpt":0.2578340796304899,"score_spread":0.2472917715970019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}