{"id":"W2300311146","doi":"10.1021/acs.jproteome.5b00719","title":"Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis","year":2016,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Hematological disorders and diagnostics","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Institute of Diabetes and Digestive and Kidney Diseases; University of Calgary; Faculty of Kinesiology, University of Calgary; U.S. Department of Veterans Affairs; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Metabolite; Genotype; Erlotinib; Integrin; Pharmacology; Medicine; Null (SQL); Osteoarthritis; Internal medicine; Pharmacogenetics; Oncology; Cancer research; Bioinformatics; Biology; Genetics; Pathology; Gene; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001757934,0.0001920291,0.0006938162,0.0001592879,0.0001611854,0.00008180924,0.0002028293,0.0001320692,0.0002801403],"category_scores_gemma":[0.003909817,0.0000778368,0.000159328,0.0001930218,0.0005045974,0.0001207677,0.00008666977,0.0005135467,0.00005907024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009546106,"about_ca_system_score_gemma":0.0002034981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001042905,"about_ca_topic_score_gemma":0.0000173202,"domain_scores_codex":[0.9972807,0.0005846694,0.0006176291,0.0002169704,0.0007821281,0.0005179029],"domain_scores_gemma":[0.9970114,0.001308201,0.0002525423,0.0002615945,0.0007966675,0.0003695588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01805375,0.003205579,0.02164925,0.001138624,0.001030417,0.0008211935,0.003228246,3.620926e-7,0.6351103,0.002069149,0.03438507,0.2793081],"study_design_scores_gemma":[0.1087319,0.05082395,0.08898827,0.006993698,0.0007855473,0.004102392,0.01436762,0.00008632516,0.6274829,0.008601542,0.08781447,0.001221382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478496,0.01082462,0.000110385,0.03873436,0.00005982222,0.001923033,0.0002259256,0.00001163813,0.0002606335],"genre_scores_gemma":[0.9915842,0.005287346,0.0005467921,0.0002687503,0.0001668811,0.000144339,0.000005831581,0.00002731304,0.001968487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2780867,"threshold_uncertainty_score":0.4680699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05755634879665199,"score_gpt":0.350777977358765,"score_spread":0.293221628562113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}