{"id":"W2300515179","doi":"10.1016/j.kint.2016.01.014","title":"Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events","year":2016,"lang":"en","type":"article","venue":"Kidney International","topic":"Dialysis and Renal Disease Management","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"Providence Health Care; University of Manitoba; Université de Montréal; Memorial University of Newfoundland; University of British Columbia; McMaster University; London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Trimethylamine N-oxide; Hazard ratio; Interquartile range; Kidney disease; Medicine; Internal medicine; Confidence interval; Renal function; Prospective cohort study; Quartile; Risk factor; Gastroenterology; Endocrinology; Trimethylamine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003152569,0.0002688596,0.0004039602,0.0002966194,0.00008982309,0.00002836388,0.0002148759,0.00006521128,0.001503831],"category_scores_gemma":[0.002622739,0.0001720735,0.0004809335,0.0002406694,0.00006919273,0.0002106156,0.00008264863,0.0001009212,0.0001564978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007271635,"about_ca_system_score_gemma":0.0007433592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008173243,"about_ca_topic_score_gemma":0.00001061816,"domain_scores_codex":[0.9975489,0.0001189983,0.000408468,0.0005024097,0.001094929,0.000326239],"domain_scores_gemma":[0.9978278,0.00005378138,0.0001738965,0.0005000419,0.0003190202,0.00112546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005393743,0.006935028,0.6463606,0.0004036044,0.05434358,0.001585938,0.0001496713,0.0007844564,0.08494844,0.006099446,0.1495633,0.04343221],"study_design_scores_gemma":[0.01678677,0.0001783116,0.8902833,0.001623168,0.002352643,0.000006477371,0.00001037338,0.00117353,0.002168048,0.0004352171,0.08451793,0.0004641813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9405674,0.0006608016,0.01679646,0.02284894,0.001177062,0.002349336,0.003887501,0.0004853618,0.01122718],"genre_scores_gemma":[0.9852095,0.00004559382,0.0004860467,0.001402904,0.0002432514,0.0001208132,0.002407623,0.00004658,0.01003774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2439227,"threshold_uncertainty_score":0.9994089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071528828132435,"score_gpt":0.2738793293729677,"score_spread":0.2531640410916433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}