{"id":"W2300659078","doi":"10.1200/jco.2013.31.4_suppl.lba5","title":"REGARD: A phase III, randomized, double-blinded trial of ramucirumab and best supportive care (BSC) versus placebo and BSC in the treatment of metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing combination therapy.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Ramucirumab; Medicine; Internal medicine; Clinical endpoint; Hazard ratio; Progression-free survival; Gastroenterology; Placebo; Cancer; Oncology; Phases of clinical research; Randomized controlled trial; Toxicity; Chemotherapy; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001974138,0.0002165736,0.001925614,0.0003086769,0.00006810124,0.00002102319,0.00007323847,0.000108288,0.0000444497],"category_scores_gemma":[0.001268321,0.0001070061,0.0003475645,0.0001869807,0.0001799799,0.0001648176,0.00002621625,0.0002890525,2.520078e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001476417,"about_ca_system_score_gemma":0.0003988271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007648911,"about_ca_topic_score_gemma":0.00008072877,"domain_scores_codex":[0.9965442,0.0005937032,0.001992357,0.0002329167,0.0004351039,0.0002017213],"domain_scores_gemma":[0.9933137,0.004323004,0.001821066,0.0001436874,0.0001958597,0.0002027325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.83058,0.003324181,0.01027313,0.00006669713,0.0005450641,0.0003478919,0.0013677,0.00001003552,0.0000032639,0.0000140084,0.00003338938,0.1534346],"study_design_scores_gemma":[0.8399232,0.1421059,0.0123528,0.0002027912,0.001858928,0.00003580224,0.002763439,0.0005768398,0.00001917962,0.00003428723,0.00006344345,0.00006342118],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931378,0.001228504,0.00008548333,0.001353626,0.0005091003,0.003621974,0.000002993621,0.00000462453,0.00005587258],"genre_scores_gemma":[0.9968948,0.00192327,0.0006758935,0.00007154798,0.0002319866,0.000128348,0.00001306095,0.00001276475,0.00004833189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1533712,"threshold_uncertainty_score":0.436358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1596108721350184,"score_gpt":0.4579740626354947,"score_spread":0.2983631905004763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}