{"id":"W2300785998","doi":"10.1002/bies.201500122","title":"Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants","year":2016,"lang":"en","type":"article","venue":"BioEssays","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Histone code; Histone methylation; Epigenome; Histone H2A; Histone methyltransferase; Histone H1; Histone; Biology; Epigenomics; Genetics; Nucleosome; Cell biology; Histone octamer; DNA methylation; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288294,0.000203594,0.0001936317,0.00004627762,0.0001511116,0.00001995523,0.0001950092,0.0001627553,0.0002054003],"category_scores_gemma":[0.00005895324,0.000152357,0.00005963228,0.00005241025,0.0001770585,0.00001293827,0.0001187129,0.00005663446,0.00004364945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064,"about_ca_system_score_gemma":0.00007472421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003234638,"about_ca_topic_score_gemma":0.0001078307,"domain_scores_codex":[0.9987809,0.00005466413,0.0002458029,0.0005342057,0.000136585,0.0002478149],"domain_scores_gemma":[0.9991871,0.00001664293,0.0001326862,0.0004705206,0.00006228785,0.0001307644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004863896,0.00007595247,0.0011741,0.00001020161,0.00004579664,0.000003252684,0.0001269808,5.449526e-7,0.9532943,0.0001455363,0.002202096,0.0428726],"study_design_scores_gemma":[0.002337082,0.0004066757,0.09457663,0.0001824353,0.000112036,0.00002843151,0.000141501,0.00003690751,0.577355,0.0009403523,0.322872,0.001011046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810855,0.01068669,0.005964966,0.000804598,0.0003484794,0.0001696578,0.00008191514,0.00002584781,0.000832368],"genre_scores_gemma":[0.991938,0.001591817,0.001133786,0.0001481178,0.0002608921,0.00004738943,0.00007763389,0.00003169419,0.004770646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3759393,"threshold_uncertainty_score":0.6212938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371873037705258,"score_gpt":0.2840666585312657,"score_spread":0.2703479281542132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}