{"id":"W2300785998","doi":"10.1002/bies.201500122","title":"Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants","year":2016,"lang":"en","type":"article","venue":"BioEssays","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Histone code; Histone methylation; Epigenome; Histone H2A; Histone methyltransferase; Histone H1; Histone; Biology; Epigenomics; Genetics; Nucleosome; Cell biology; Histone octamer; DNA methylation; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631609,0.0002344137,0.0002724779,0.0001447017,0.0001217579,0.0002748852,0.0002528546,0.0002737888,0.001060919],"category_scores_gemma":[0.0002555806,0.0001606869,0.0002489513,0.0001047925,0.0001640406,0.0002289027,0.0003476272,0.0004881207,0.0004733889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661378,"about_ca_system_score_gemma":0.0001958417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003323475,"about_ca_topic_score_gemma":0.0006631589,"domain_scores_codex":[0.999858,0.00001601922,0.00001143472,0.00003966909,0.00004124024,0.00003357429],"domain_scores_gemma":[0.999769,0.00002714805,0.00007677594,0.00002950718,0.00003225067,0.00006525199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001880795,0.00002222602,0.0005648857,0.00006377011,0.00002193999,0.0001159563,0.00001372465,0.0001085191,0.9935473,0.0003070139,0.000303166,0.00474346],"study_design_scores_gemma":[0.0000324534,0.0003995758,0.006994489,0.00000930532,0.00002292734,0.0009068139,0.00001804833,0.001295449,0.9764137,0.0001768525,0.0137222,0.000008226802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982134,0.007629455,0.006832881,0.0003445667,0.0001179991,0.00002624923,0.0005893747,0.000303192,0.002022238],"genre_scores_gemma":[0.9904501,0.001351166,0.00265461,0.0001661804,0.00002858176,0.00001479653,0.001056803,0.00003948057,0.004238304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060919,"threshold_uncertainty_score":0.003549159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371873037705258,"score_gpt":0.2840666585312657,"score_spread":0.2703479281542132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}