{"id":"W2300971307","doi":"10.1038/nature17408","title":"Derivation and differentiation of haploid human embryonic stem cells","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Azrieli Foundation; Rosetrees Trust; Russell Berrie Foundation","keywords":"Ploidy; Biology; Embryonic stem cell; Somatic cell; Genetics; Stem cell; Induced pluripotent stem cell; Cell biology; Gamete; Cellular differentiation; Reprogramming; Gene; Human fertilization","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005351132,0.0002373866,0.0002508422,0.0004474711,0.0004375705,0.0004842583,0.0004338076,0.000215073,0.00498567],"category_scores_gemma":[0.0003739653,0.0003575645,0.0001915502,0.000369379,0.0003044661,0.0002031813,0.0004269134,0.0007736252,0.002732917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202451,"about_ca_system_score_gemma":0.0005350112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000671472,"about_ca_topic_score_gemma":0.001350126,"domain_scores_codex":[0.9997864,0.00002783897,0.00005174925,0.00003363004,0.00007464809,0.00002576288],"domain_scores_gemma":[0.9998,0.00003885241,0.00001659349,0.00006048613,0.00004472328,0.00003941907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001293263,0.00003018321,0.000748088,0.00009894572,0.000008732824,0.0002435254,0.0002740841,0.0004083896,0.98041,0.004131998,0.0008824728,0.01263402],"study_design_scores_gemma":[0.00005748304,0.0001749287,0.00512461,0.00005133216,0.00002668332,0.0008530634,0.0001367688,0.001243015,0.9029875,0.001390242,0.08793506,0.00001923992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.709424,0.003994553,0.2109734,0.0008592567,0.0006694652,0.003843782,0.02512093,0.001045828,0.04406888],"genre_scores_gemma":[0.6713816,0.005217046,0.222277,0.0005430631,0.00006498465,0.002095629,0.03168346,0.0004933205,0.06624395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00498567,"threshold_uncertainty_score":0.01667869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008397907756373772,"score_gpt":0.2542966829002259,"score_spread":0.2458987751438522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}