{"id":"W2300971307","doi":"10.1038/nature17408","title":"Derivation and differentiation of haploid human embryonic stem cells","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Azrieli Foundation; Rosetrees Trust; Russell Berrie Foundation","keywords":"Ploidy; Biology; Embryonic stem cell; Somatic cell; Genetics; Stem cell; Induced pluripotent stem cell; Cell biology; Gamete; Cellular differentiation; Reprogramming; Gene; Human fertilization","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007265199,0.00006196708,0.00006500025,0.00003251177,0.00003234426,0.000006089746,0.00008364739,0.0004498184,0.00001127947],"category_scores_gemma":[0.00001075991,0.00004283322,0.00002632154,0.0000353227,0.00003412628,0.000003211528,0.00006484266,0.0001440952,0.000002973094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008439226,"about_ca_system_score_gemma":0.00001375527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001526407,"about_ca_topic_score_gemma":0.000008180971,"domain_scores_codex":[0.9994935,0.00003231463,0.00008068876,0.0001666328,0.0001243415,0.0001025249],"domain_scores_gemma":[0.9996787,0.000008190448,0.00005073984,0.0001587727,0.00007316978,0.00003043214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001661791,0.00001488706,0.002712479,0.00002630467,0.00001397387,2.649675e-7,0.000005987521,3.478239e-7,0.9936374,0.0001078683,0.0008328593,0.002630965],"study_design_scores_gemma":[0.0003810781,0.00007905588,0.02505069,0.00001811394,0.000004577004,0.000001179994,0.000005599456,0.00000448452,0.971355,0.00005156689,0.002992273,0.00005634274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983741,0.0007021833,0.0003144842,0.0002677151,0.00005274587,0.00009538815,0.00001312533,0.000004814913,0.0001754212],"genre_scores_gemma":[0.9975263,0.00017283,0.00003529644,0.0000366168,0.0000575528,0.000003540651,0.00002147792,0.000008738476,0.002137649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02233821,"threshold_uncertainty_score":0.3469412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008397907756373772,"score_gpt":0.2542966829002259,"score_spread":0.2458987751438522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}