{"id":"W2301007008","doi":"10.1101/gad.275529.115","title":"Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Innovative Medicines Initiative; European Commission; Canada Foundation for Innovation; Wellcome; AbbVie; Lustgarten Foundation; Tobacco-Related Disease Research Program; Wellcome Trust","keywords":"Pancreatic cancer; Biology; Lysine; Methyltransferase; Cancer research; Kinase; Transferase; Irinotecan; Adenocarcinoma; Cancer; Enzyme; Cell biology; Genetics; Gene; Biochemistry; Colorectal cancer; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083952,0.0002292963,0.0001958752,0.0001253102,0.0001346904,0.0002714156,0.0001173171,0.000147899,0.0006735862],"category_scores_gemma":[0.00007715516,0.0001378585,0.0001507826,0.00009621392,0.0002150335,0.0001812017,0.0003465427,0.0003851384,0.0001866551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826397,"about_ca_system_score_gemma":0.0001522891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002687695,"about_ca_topic_score_gemma":0.0007040707,"domain_scores_codex":[0.9999317,0.00001217966,0.000005508698,0.00001930688,0.00001550491,0.00001587663],"domain_scores_gemma":[0.9999323,0.000006898149,0.00002170592,0.000008244374,0.000007028597,0.00002380575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001556167,0.00001129761,0.0005731885,0.00001481237,0.000003959316,0.00004482804,0.000008299798,0.00008375005,0.9977448,0.0001088988,0.00004929293,0.001201387],"study_design_scores_gemma":[0.00002574687,0.000260811,0.02136962,0.00000400013,0.00001338395,0.0002931929,0.00004601985,0.001736888,0.9725446,0.0002156544,0.003484229,0.0000059168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939418,0.001653837,0.002577005,0.0001703736,0.00002839484,0.0000107683,0.0002113478,0.0001123385,0.001294158],"genre_scores_gemma":[0.9973176,0.0005619116,0.000855803,0.00003165353,0.000007789246,0.000009537398,0.0001212804,0.00001224101,0.001082118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006735862,"threshold_uncertainty_score":0.002253413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209803651687022,"score_gpt":0.2586250402891298,"score_spread":0.2465270037722596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}