{"id":"W2301007008","doi":"10.1101/gad.275529.115","title":"Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Innovative Medicines Initiative; European Commission; Canada Foundation for Innovation; Wellcome; AbbVie; Lustgarten Foundation; Tobacco-Related Disease Research Program; Wellcome Trust","keywords":"Pancreatic cancer; Biology; Lysine; Methyltransferase; Cancer research; Kinase; Transferase; Irinotecan; Adenocarcinoma; Cancer; Enzyme; Cell biology; Genetics; Gene; Biochemistry; Colorectal cancer; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000262225,0.0001259838,0.0001266143,0.00002586161,0.00007286773,0.000009942568,0.0001380156,0.00006972757,0.00005066299],"category_scores_gemma":[0.00003537113,0.00007272793,0.00004090933,0.00007751271,0.00005148849,0.000003191799,0.00003804562,0.00002047709,0.000002931643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002012977,"about_ca_system_score_gemma":0.0001491426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000454145,"about_ca_topic_score_gemma":0.00009360573,"domain_scores_codex":[0.9991139,0.00007314618,0.0002634812,0.0002194097,0.0001689445,0.0001611125],"domain_scores_gemma":[0.9994903,0.00003228932,0.00009332157,0.0001891648,0.0001535182,0.00004147439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001671274,0.00003555705,0.008961872,0.00001784947,0.00007754775,1.484537e-7,0.00008385549,0.00002292941,0.8658925,0.00001255846,0.0001472027,0.1247313],"study_design_scores_gemma":[0.0003042957,0.00005914925,0.006301246,0.00003622692,0.00002629086,2.905943e-7,0.00002208952,0.000008846713,0.9780593,0.0000905548,0.01496678,0.0001249122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703447,0.009952545,0.01854579,0.0007207902,0.00007269163,0.0002419395,0.00004597351,0.000005783769,0.00006983235],"genre_scores_gemma":[0.9958016,0.002048098,0.001128584,0.00003910464,0.0000581553,0.00009656683,0.00007992129,0.00001504124,0.0007329229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1246063,"threshold_uncertainty_score":0.2965759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209803651687022,"score_gpt":0.2586250402891298,"score_spread":0.2465270037722596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}