{"id":"W2301030872","doi":"10.1371/journal.pgen.1005498","title":"A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute on Drug Abuse; Turun Yliopistollinen Keskussairaala; Paavo Nurmen Säätiö; Tampereen Tuberkuloosisäätiö; Sydäntutkimussäätiö; Juho Vainion Säätiö; National Institute on Alcohol Abuse and Alcoholism; University of Toronto; China Scholarship Council; Suomen Kulttuurirahasto; Academy of Finland; Kela; National Institute of Mental Health; Terveyden ja hyvinvoinnin laitos; Emil Aaltosen Säätiö; Pfizer; Broad Institute; Wellcome Trust; Foundation for Cardiovascular Research; Yrjö Jahnssonin Säätiö","keywords":"CYP2A6; Genome-wide association study; Single-nucleotide polymorphism; Nicotine; Biology; Cotinine; Genetics; Genetic association; SNP; Heritability; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238524,0.0004885792,0.000578062,0.000876874,0.0005731218,0.0007323966,0.0003561558,0.0008898489,0.002304372],"category_scores_gemma":[0.003483974,0.0002494874,0.00112657,0.001894986,0.0002911418,0.0002607991,0.0004128435,0.0006352291,0.0002228887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134736,"about_ca_system_score_gemma":0.0003449815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003481486,"about_ca_topic_score_gemma":0.00367443,"domain_scores_codex":[0.9989218,0.0003641231,0.00007097262,0.0004273726,0.0001272898,0.0000884852],"domain_scores_gemma":[0.9987897,0.0005152797,0.0002683248,0.0001872727,0.0001114597,0.0001278868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001399693,0.00009374133,0.9721416,0.00008618044,0.002956044,0.000518535,0.00009056171,0.0002729602,0.01465466,0.0002337849,0.0003287909,0.007223467],"study_design_scores_gemma":[0.00005094913,0.0001731918,0.996108,0.00001048277,0.00119736,0.000489629,0.00003417641,0.0005447318,0.0006149989,0.000198883,0.0005691426,0.00000832393],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993895,0.001974643,0.00193489,0.0002024562,0.00003801994,0.00001937226,0.0009987021,0.00003909062,0.000897907],"genre_scores_gemma":[0.9976633,0.0003956384,0.0009641546,0.00004996836,0.00002461071,0.0000140799,0.0005283401,0.000007602654,0.0003523792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003481486,"threshold_uncertainty_score":0.007708907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07209347558388444,"score_gpt":0.3063620495874191,"score_spread":0.2342685740035347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}