{"id":"W2301030872","doi":"10.1371/journal.pgen.1005498","title":"A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute on Drug Abuse; Turun Yliopistollinen Keskussairaala; Paavo Nurmen Säätiö; Tampereen Tuberkuloosisäätiö; Sydäntutkimussäätiö; Juho Vainion Säätiö; National Institute on Alcohol Abuse and Alcoholism; University of Toronto; China Scholarship Council; Suomen Kulttuurirahasto; Academy of Finland; Kela; National Institute of Mental Health; Terveyden ja hyvinvoinnin laitos; Emil Aaltosen Säätiö; Pfizer; Broad Institute; Wellcome Trust; Foundation for Cardiovascular Research; Yrjö Jahnssonin Säätiö","keywords":"CYP2A6; Genome-wide association study; Single-nucleotide polymorphism; Nicotine; Biology; Cotinine; Genetics; Genetic association; SNP; Heritability; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002560141,0.00006991356,0.0002425407,0.00009324473,0.000009739279,0.000003365195,0.00005241321,0.00006526052,0.00002560148],"category_scores_gemma":[0.0002968047,0.00006324115,0.00003740029,0.0001995491,0.00001220427,0.0000159802,0.00002635844,0.00005630477,0.000001904113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000617778,"about_ca_system_score_gemma":0.00006218364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001713392,"about_ca_topic_score_gemma":0.000006470431,"domain_scores_codex":[0.9989447,0.00005103203,0.000286012,0.0001039277,0.0005184908,0.00009583647],"domain_scores_gemma":[0.9990444,0.0000465102,0.0002185767,0.0002119292,0.0004164847,0.00006213655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004870363,0.001195994,0.9600188,0.00002228835,0.000136257,8.91449e-7,0.001956376,0.000009666875,0.03636353,0.000001329672,0.00006760587,0.0001785735],"study_design_scores_gemma":[0.002029958,0.000369066,0.9331712,0.00001261842,0.0007538757,4.706054e-7,0.0008245275,0.00007933719,0.06252467,0.00001967876,0.0001628789,0.00005174498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989129,0.0002057322,0.00001712263,0.00006017842,0.0000945517,0.0003319586,0.000006271344,0.00001519908,0.0003561252],"genre_scores_gemma":[0.9996212,0.00001442423,0.0001168917,0.00002424062,0.00004453438,0.00001002465,0.0000161732,0.00001364094,0.0001389199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02684761,"threshold_uncertainty_score":0.2578899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07209347558388444,"score_gpt":0.3063620495874191,"score_spread":0.2342685740035347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}