{"id":"W2301047976","doi":"10.1186/s13567-016-0329-x","title":"Regulation of tracheal antimicrobial peptide gene expression in airway epithelial cells of cattle","year":2016,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs; Beef Farmers of Ontario; University of Guelph","keywords":"TLR2; Biology; Innate immune system; Interleukin 8; TLR4; Glucocorticoid receptor; Agonist; Glucocorticoid; Downregulation and upregulation; Antimicrobial peptides; Toll-like receptor; Receptor; Signal transduction; Defensin; Microbiology; Molecular biology; Immunology; Immune system; Cell biology; Cytokine; Gene; Antimicrobial; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006798662,0.0001154022,0.0002873542,0.0003037419,0.00007924323,0.000004446551,0.0002322412,0.0001982644,0.0005528323],"category_scores_gemma":[0.00004463514,0.0000841806,0.00008246908,0.0001706185,0.0006375524,0.0001516923,0.000188847,0.0002081072,0.00009338213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004454658,"about_ca_system_score_gemma":0.00006752487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002309792,"about_ca_topic_score_gemma":0.00001007528,"domain_scores_codex":[0.9984376,0.0004552013,0.0003729875,0.0002602354,0.00007825315,0.0003956845],"domain_scores_gemma":[0.9991901,0.0002874351,0.0001102967,0.000276865,0.0001167253,0.00001859322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001071448,0.0002180266,0.0006359834,0.00007419884,0.00001372291,0.0000050488,0.0003363355,0.000008189349,0.9926032,0.00003714903,0.001919426,0.003077302],"study_design_scores_gemma":[0.001035119,0.0007571186,0.007501714,0.0001949877,0.000002730247,0.00003095364,0.00009666059,0.000001493766,0.9890526,0.00005356318,0.001177072,0.00009598788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985278,0.00009829645,0.0001792059,0.000147262,0.0001919302,0.0002071017,0.000166208,0.00001141747,0.0004707889],"genre_scores_gemma":[0.9962712,0.0001166334,0.0004129633,0.000004700459,0.00004039447,0.000007491116,0.00002069935,0.00001666436,0.003109277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006865731,"threshold_uncertainty_score":0.6053126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05512630635411221,"score_gpt":0.3148894511145466,"score_spread":0.2597631447604344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}