{"id":"W2301047976","doi":"10.1186/s13567-016-0329-x","title":"Regulation of tracheal antimicrobial peptide gene expression in airway epithelial cells of cattle","year":2016,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs; Beef Farmers of Ontario; University of Guelph","keywords":"TLR2; Biology; Innate immune system; Interleukin 8; TLR4; Glucocorticoid receptor; Agonist; Glucocorticoid; Downregulation and upregulation; Antimicrobial peptides; Toll-like receptor; Receptor; Signal transduction; Defensin; Microbiology; Molecular biology; Immunology; Immune system; Cell biology; Cytokine; Gene; Antimicrobial; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706699,0.0001713544,0.0003383239,0.0003659693,0.0003271458,0.0004704278,0.0001353103,0.0003710802,0.0009977316],"category_scores_gemma":[0.0002016586,0.000185924,0.0003241307,0.000366213,0.0002561661,0.0002086317,0.0001983593,0.0005442564,0.000424284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005683015,"about_ca_system_score_gemma":0.0002530386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003714964,"about_ca_topic_score_gemma":0.003716509,"domain_scores_codex":[0.9997274,0.00003763686,0.00001974864,0.00006774286,0.00005597163,0.00009142404],"domain_scores_gemma":[0.9998437,0.00003982561,0.00003253858,0.000009908197,0.00003471614,0.00003933978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000212194,0.00001809848,0.002439266,0.00005882005,0.000004582511,0.000126331,0.00015591,0.00002101925,0.9959865,0.00003156617,0.00003810801,0.0009074753],"study_design_scores_gemma":[0.00005680715,0.001385428,0.3715071,0.0000614165,0.0000998921,0.002145977,0.002947146,0.001225605,0.609331,0.0002024848,0.01099792,0.00003924513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949975,0.002637967,0.0006123687,0.00008366205,0.00001940381,0.00001620856,0.0007186966,0.00001176617,0.0009023722],"genre_scores_gemma":[0.9932234,0.001724359,0.0009167606,0.0001321949,0.00002315626,0.00005349358,0.001146181,0.00001043789,0.002769994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003714964,"threshold_uncertainty_score":0.007386684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05512630635411221,"score_gpt":0.3148894511145466,"score_spread":0.2597631447604344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}