{"id":"W2301196075","doi":"10.1093/cvr/cvw053","title":"Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms","year":2016,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"LDL receptor; PCSK9; Internal medicine; Endocrinology; Apolipoprotein E; Kexin; Apolipoprotein B; Lipoprotein; Cholesterol; Lipogenesis; Chemistry; Biology; Medicine; Lipid metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326658,0.0003454185,0.0002513315,0.0002467391,0.0001212916,0.0002714166,0.0001321915,0.0001771783,0.00200212],"category_scores_gemma":[0.00009805424,0.0001590747,0.0003198564,0.0001539236,0.0003396058,0.0001363078,0.0002185586,0.0006200741,0.000560544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003083828,"about_ca_system_score_gemma":0.0001887026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000790781,"about_ca_topic_score_gemma":0.0007900711,"domain_scores_codex":[0.9998415,0.00001779168,0.00001512794,0.00003491425,0.0000529827,0.00003758921],"domain_scores_gemma":[0.999871,0.0000115239,0.00004598026,0.00001620606,0.00001368936,0.00004149038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001054659,0.00006284614,0.0009891905,0.00004471099,0.0000118311,0.00007952509,0.00001108651,0.00004697416,0.9953995,0.00006429006,0.0000757205,0.002159649],"study_design_scores_gemma":[0.00008505649,0.0005996069,0.02186413,0.000008406735,0.00003334795,0.0004617945,0.00003195635,0.0005471807,0.9743652,0.00006481083,0.00193113,0.000007446711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957116,0.001004141,0.001591966,0.0001099246,0.00003321183,0.00002726798,0.0004174687,0.0001143261,0.0009900221],"genre_scores_gemma":[0.9937013,0.0008197757,0.001338934,0.00004905339,0.0000186002,0.00003109797,0.0005224318,0.00002193573,0.003496913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200212,"threshold_uncertainty_score":0.006697774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06225339044670478,"score_gpt":0.3110566996130619,"score_spread":0.2488033091663572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}