{"id":"W23013320","doi":"10.1007/978-1-4615-1321-6_25","title":"Tumor Necrosis Factor-α, Sphingomyelinase and Ceramides Activate Tyrosine Kinase, P21ras and Phosphatidylinositol 3-Kinase: Implications for Glucose Transport and Insulin Resistance","year":2001,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Insulin receptor; Insulin resistance; Insulin receptor substrate; IRS1; IRS2; Internal medicine; Endocrinology; Tyrosine phosphorylation; GRB10; Receptor tyrosine kinase; Insulin; Tyrosine kinase; Chemistry; Biology; Kinase; Cell biology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001968009,0.0005213077,0.0002299989,0.0004675571,0.0002669017,0.0008934988,0.0002511348,0.0005514091,0.00107399],"category_scores_gemma":[0.0002570589,0.0001933226,0.000271143,0.000424323,0.0004132148,0.0009448121,0.0002627631,0.0006234055,0.0003958515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000752603,"about_ca_system_score_gemma":0.0002719357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004559981,"about_ca_topic_score_gemma":0.0004871087,"domain_scores_codex":[0.9999173,0.00001229782,0.000005563963,0.00001022326,0.00001939533,0.00003519488],"domain_scores_gemma":[0.9999167,0.00001454574,0.00002302505,0.000009364932,0.00001240929,0.00002404991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006172933,0.000154147,0.002737696,0.0001720961,0.000033774,0.001319878,0.0001133695,0.000644511,0.9638861,0.008915235,0.0004923522,0.01535805],"study_design_scores_gemma":[0.0003060339,0.0006151996,0.02459366,0.00002906486,0.000105408,0.003394805,0.0003808674,0.002430303,0.9435859,0.0105096,0.01402472,0.00002436166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621366,0.02505695,0.003538427,0.001988431,0.000218691,0.00002459568,0.0003044615,0.0001002388,0.006631556],"genre_scores_gemma":[0.9818049,0.01289646,0.0008824369,0.0001324576,0.00009222031,0.0000202857,0.0001962225,0.00001230219,0.003962706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107399,"threshold_uncertainty_score":0.005460501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071648375260884,"score_gpt":0.3215503375545807,"score_spread":0.3008338538019719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}