{"id":"W23013320","doi":"10.1007/978-1-4615-1321-6_25","title":"Tumor Necrosis Factor-α, Sphingomyelinase and Ceramides Activate Tyrosine Kinase, P21ras and Phosphatidylinositol 3-Kinase: Implications for Glucose Transport and Insulin Resistance","year":2001,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Insulin receptor; Insulin resistance; Insulin receptor substrate; IRS1; IRS2; Internal medicine; Endocrinology; Tyrosine phosphorylation; GRB10; Receptor tyrosine kinase; Insulin; Tyrosine kinase; Chemistry; Biology; Kinase; Cell biology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009941331,0.0002044519,0.0002627992,0.00006401903,0.0001479108,0.000009323113,0.00005414523,0.000101183,0.000005773068],"category_scores_gemma":[0.00005670724,0.0001714355,0.00002033662,0.00008691092,0.000473292,0.00002706445,0.00004565526,0.00006614112,6.182291e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001246504,"about_ca_system_score_gemma":0.00001478876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004914225,"about_ca_topic_score_gemma":0.0001050219,"domain_scores_codex":[0.998965,0.00003181153,0.0002716016,0.000475169,0.00003590319,0.000220537],"domain_scores_gemma":[0.9995665,0.00005371699,0.0000974818,0.0001317151,0.00003521332,0.0001153731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005159182,0.00005853586,0.03058303,0.00005978428,0.00001279278,0.000003847488,0.0001756472,9.124362e-7,0.9379938,0.001208788,0.0000136158,0.02937332],"study_design_scores_gemma":[0.004118683,0.0011027,0.04972278,0.0001878047,0.00002472833,0.00004990722,0.0005585984,0.00005001488,0.8915939,0.002665427,0.04953035,0.0003951484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8295349,0.1683096,0.0007117637,0.0009174688,0.00004499405,0.0003836791,0.00004397719,0.000010192,0.00004335694],"genre_scores_gemma":[0.9714213,0.02620094,0.001403844,0.0005405216,0.0001212534,0.0001232224,0.0001476568,0.00001435722,0.00002690534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1421087,"threshold_uncertainty_score":0.6990938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071648375260884,"score_gpt":0.3215503375545807,"score_spread":0.3008338538019719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}