{"id":"W2301368381","doi":"10.1021/acsmedchemlett.5b00447","title":"Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of Na<sub>V</sub>1.7 with Efficacy in Rodent Pain Models","year":2016,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Analgesic; Sodium channel; Pharmacology; In vivo; Gene isoform; Potency; Drug discovery; Aryl; Chemistry; Medicine; In vitro; Biochemistry; Biology; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551886,0.0004309285,0.0003137175,0.0001633665,0.00012673,0.0001999412,0.0003066273,0.0002412024,0.0008937386],"category_scores_gemma":[0.0001609112,0.000130207,0.0002048439,0.0001186234,0.0002420403,0.0002428454,0.0002141632,0.0005322075,0.0003155058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942302,"about_ca_system_score_gemma":0.000261505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003852217,"about_ca_topic_score_gemma":0.00149435,"domain_scores_codex":[0.9999295,0.00001300706,0.0000056788,0.000009977646,0.00002189643,0.00001977555],"domain_scores_gemma":[0.9999168,0.00001169848,0.00002967268,0.000005160919,0.00001857319,0.0000181089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003676137,0.0001835474,0.0003439692,0.0001698075,0.00002656152,0.0001813662,0.00007554343,0.0008308879,0.9685144,0.0008576686,0.0003936046,0.028055],"study_design_scores_gemma":[0.0002236118,0.00605417,0.002232259,0.00002811298,0.00008009033,0.0005890504,0.00004712688,0.001744408,0.9740002,0.0002872374,0.01468845,0.00002526406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702114,0.01056306,0.01168465,0.0003363005,0.00008534643,0.0003024824,0.0004026675,0.0001951257,0.006218938],"genre_scores_gemma":[0.9648259,0.01534796,0.01404343,0.0002721578,0.000058301,0.0001850729,0.0005943971,0.0000369185,0.004635843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008937386,"threshold_uncertainty_score":0.002989888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006077221299118488,"score_gpt":0.2040985847617672,"score_spread":0.1980213634626488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}