{"id":"W2301386529","doi":"10.1093/gbe/evw061","title":"Genome Hotspots for Nucleotide Substitutions and the Evolution of Influenza A (H1N1) Human Strains","year":2016,"lang":"en","type":"letter","venue":"Genome Biology and Evolution","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nonsynonymous substitution; Biology; Neuraminidase; Antigenic drift; Negative selection; Antigenic shift; Genetics; Hemagglutinin (influenza); Influenza A virus; Viral evolution; Virology; Antigenic variation; Genome; Evolutionary biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003593086,0.0001264856,0.0001904413,0.0002988572,0.0004015147,0.0004093382,0.0001998568,0.002035343,0.001421323],"category_scores_gemma":[0.001518929,0.0001017311,0.0001073868,0.0003781504,0.0004322143,0.0003874972,0.0001684813,0.0007590569,0.0006848093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386037,"about_ca_system_score_gemma":0.000105925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005398749,"about_ca_topic_score_gemma":0.000669621,"domain_scores_codex":[0.9997373,0.00009404818,0.00002329944,0.00006010892,0.00005100473,0.00003410653],"domain_scores_gemma":[0.9994204,0.0002396575,0.0001549751,0.00005778014,0.00007321949,0.00005389391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003546943,0.000278161,0.5763763,0.0005228118,0.0001802457,0.08083926,0.003118028,0.001252354,0.07189605,0.009228398,0.05998755,0.192774],"study_design_scores_gemma":[0.0001731289,0.0007896898,0.6082464,0.0002606824,0.0001574498,0.1852991,0.002686645,0.004785823,0.01719584,0.012901,0.1674195,0.00008457752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.898894,0.01688558,0.001464291,0.06199174,0.001380538,0.00004016051,0.0003031768,0.0001050134,0.01893561],"genre_scores_gemma":[0.9812656,0.003608224,0.0005035677,0.009645297,0.003028695,0.0000137333,0.00007167365,0.00001314413,0.001850015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002035343,"threshold_uncertainty_score":0.004754841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05845156295247009,"score_gpt":0.350222764723017,"score_spread":0.2917712017705469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}