{"id":"W2301386529","doi":"10.1093/gbe/evw061","title":"Genome Hotspots for Nucleotide Substitutions and the Evolution of Influenza A (H1N1) Human Strains","year":2016,"lang":"en","type":"letter","venue":"Genome Biology and Evolution","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nonsynonymous substitution; Biology; Neuraminidase; Antigenic drift; Negative selection; Antigenic shift; Genetics; Hemagglutinin (influenza); Influenza A virus; Viral evolution; Virology; Antigenic variation; Genome; Evolutionary biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0008034689,0.0003261548,0.000731247,0.0003191512,0.0006799066,0.00001216412,0.0001586304,0.0007770999,0.00003081526],"category_scores_gemma":[0.00034396,0.000200821,0.0001791627,0.0001488046,0.003127394,0.00007653824,0.0001572603,0.0006790991,0.00001516072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004706378,"about_ca_system_score_gemma":0.0002433265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003317202,"about_ca_topic_score_gemma":0.00004815786,"domain_scores_codex":[0.9979494,0.0002153855,0.0005266338,0.0005115546,0.0001698097,0.0006272061],"domain_scores_gemma":[0.9986117,0.0002627305,0.0002842738,0.0004061635,0.0003607593,0.00007437621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007503922,0.0003047511,0.09265737,0.006825317,0.007376977,0.00007256217,0.003560865,0.00001919373,0.5949763,0.2176774,0.0668347,0.002190672],"study_design_scores_gemma":[0.006567313,0.0007842963,0.6086606,0.0001723212,0.0005641097,0.00005688572,0.000145425,0.00001468911,0.00001597514,0.01513486,0.3675094,0.0003741605],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.714015,0.06560691,0.005478507,0.2012569,0.0007070181,0.007115138,0.003495329,0.0001815839,0.002143596],"genre_scores_gemma":[0.9566294,0.001669844,0.0003214169,0.03372029,0.004697231,0.0006093973,0.0004777493,0.00006736575,0.001807297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5949603,"threshold_uncertainty_score":0.9995855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05845156295247009,"score_gpt":0.350222764723017,"score_spread":0.2917712017705469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}