{"id":"W2301468523","doi":"10.1124/dmd.115.068650","title":"The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities","keywords":"Enzyme assay; Endocrinology; Reductase; Internal medicine; Population; Enzyme; Ontogeny; Obesity; Biology; Glutathione reductase; Oxidative stress; Antioxidant; Glutathione; Biochemistry; Medicine; Glutathione peroxidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002941178,0.0001284032,0.0001543213,0.0006377617,0.0002530589,0.0003654895,0.000202362,0.0003027791,0.001935696],"category_scores_gemma":[0.0006898416,0.0002045262,0.0001708925,0.0005029684,0.0003406532,0.0002216164,0.0004030183,0.0003654956,0.0002557181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159544,"about_ca_system_score_gemma":0.0001268827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003257039,"about_ca_topic_score_gemma":0.002687467,"domain_scores_codex":[0.9997578,0.00005958109,0.000008392553,0.0001262583,0.00002253361,0.00002543632],"domain_scores_gemma":[0.9996046,0.000129448,0.00008798071,0.00006151998,0.00006705039,0.00004942741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002069899,0.0001826971,0.7429217,0.00007007413,0.0003607862,0.0007289236,0.00323009,0.0006163957,0.1784885,0.003002965,0.0006723034,0.06765568],"study_design_scores_gemma":[0.000005896881,0.00009233832,0.9966062,0.000004582363,0.00002247261,0.0004278901,0.0002085821,0.000173435,0.001077661,0.0003028596,0.00107166,0.000006306756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972017,0.0005651775,0.0007983026,0.00006504328,0.000006155465,0.00000551127,0.0003293928,0.000007585589,0.001021164],"genre_scores_gemma":[0.9978977,0.0003690913,0.000227448,0.00002644034,0.000008211547,0.000007829656,0.0002844994,0.00001123986,0.001167516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003257039,"threshold_uncertainty_score":0.006476164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004167177827036777,"score_gpt":0.2274611733537582,"score_spread":0.2232939955267215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}