{"id":"W2301468523","doi":"10.1124/dmd.115.068650","title":"The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities","keywords":"Enzyme assay; Endocrinology; Reductase; Internal medicine; Population; Enzyme; Ontogeny; Obesity; Biology; Glutathione reductase; Oxidative stress; Antioxidant; Glutathione; Biochemistry; Medicine; Glutathione peroxidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000298021,0.0001317022,0.0001591973,0.0000209508,0.0001783497,0.00001971193,0.00007930447,0.00006724004,0.000005197634],"category_scores_gemma":[0.00007914407,0.00008492285,0.00005276242,0.0000344486,0.0001921299,0.00001239091,0.00007033313,0.00003330078,7.175382e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007750468,"about_ca_system_score_gemma":0.00001457078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646094,"about_ca_topic_score_gemma":0.00008818881,"domain_scores_codex":[0.9990964,0.0001358333,0.0002388323,0.0002857445,0.00008720475,0.0001559962],"domain_scores_gemma":[0.9994217,0.00003488132,0.0001214067,0.0002716077,0.00006579974,0.00008461637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008796417,0.00004962246,0.008230178,0.00002266305,0.00002832084,2.227245e-7,0.00007675205,4.555077e-7,0.9869719,0.001693554,0.00005909872,0.002779337],"study_design_scores_gemma":[0.0006876849,0.0000394794,0.1398544,0.00001752066,0.00007218349,0.000004197935,0.00005606329,0.000008591895,0.8533094,0.005384791,0.0004164027,0.0001492255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969663,0.002019409,0.0003953918,0.0001444339,0.00007511927,0.000191464,0.0001287084,0.000005640682,0.00007352634],"genre_scores_gemma":[0.9988879,0.0004788048,0.0001480807,0.00004148742,0.0001551749,0.00002046134,0.0001942375,0.00001042022,0.00006341005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1336624,"threshold_uncertainty_score":0.3463053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004167177827036777,"score_gpt":0.2274611733537582,"score_spread":0.2232939955267215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}