{"id":"W2301486290","doi":"10.1021/acsmedchemlett.5b00372","title":"Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Universidade de Macau","keywords":"Neurodegeneration; Neuroscience; Supramolecular chemistry; Computer science; Medicine; Chemistry; Biology; Internal medicine; Crystallography; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008076498,0.0002669758,0.0001924377,0.0001026183,0.00009046075,0.0001515578,0.0002983416,0.0001954699,0.0006312985],"category_scores_gemma":[0.0001114266,0.00008166996,0.0001176153,0.00007293031,0.0001881381,0.0001211056,0.0001586042,0.00025762,0.0002305683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038673,"about_ca_system_score_gemma":0.0001390107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006054571,"about_ca_topic_score_gemma":0.0008586298,"domain_scores_codex":[0.9999427,0.00001302741,0.000002814393,0.00001233309,0.00001062688,0.00001851098],"domain_scores_gemma":[0.9999617,0.000005414821,0.00001316299,0.00000462146,0.000005731493,0.000009350951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007037594,0.00001162805,0.00004065262,0.00003201126,0.000004820388,0.00002438307,0.00000676025,0.0002017278,0.9987255,0.00009440288,0.00003041934,0.000757388],"study_design_scores_gemma":[0.0000134257,0.0002090617,0.000407875,0.000003222756,0.00001219092,0.00005415318,0.000007640665,0.001851094,0.9965466,0.0000167832,0.0008719077,0.000006099238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956104,0.0009070215,0.001946962,0.00004747981,0.0000182278,0.00002039393,0.0000914031,0.0001260521,0.001232121],"genre_scores_gemma":[0.9976216,0.000288403,0.001316565,0.00002898181,0.000005477105,0.00001602798,0.00007476273,0.00001093751,0.0006371982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006312985,"threshold_uncertainty_score":0.002204716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673168488606041,"score_gpt":0.2954091284148435,"score_spread":0.2586774435287831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}