{"id":"W2301486290","doi":"10.1021/acsmedchemlett.5b00372","title":"Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Universidade de Macau","keywords":"Neurodegeneration; Neuroscience; Supramolecular chemistry; Computer science; Medicine; Chemistry; Biology; Internal medicine; Crystallography; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002691878,0.0001398626,0.0001567283,0.00004538596,0.00008104521,0.00001975842,0.000269462,0.00005252552,0.00006276575],"category_scores_gemma":[0.0009020423,0.0001308371,0.00003810045,0.0003549899,0.0005588552,0.0001860282,0.00007086738,0.0002912157,0.00003534768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003833833,"about_ca_system_score_gemma":0.00007649429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005926841,"about_ca_topic_score_gemma":4.363313e-8,"domain_scores_codex":[0.9980876,0.000169821,0.0002384704,0.0004637492,0.0007279326,0.0003124581],"domain_scores_gemma":[0.9992545,0.0001293177,0.0001047593,0.0002361083,0.00005118825,0.0002241108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000687041,0.00006495439,0.0000326096,0.00002752389,0.000001072467,0.00009775436,0.00007230505,0.00001899896,0.9812448,0.000005806567,0.01825082,0.00011462],"study_design_scores_gemma":[0.0005255145,0.00008601133,0.000002842213,0.00001579793,0.000009951142,0.00008625779,0.00002340919,0.0001040288,0.9970285,0.00001223962,0.002002873,0.0001025473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923018,0.00002964138,0.0001515685,0.006814013,0.0002217889,0.000131027,0.00001360835,0.00004102459,0.0002955178],"genre_scores_gemma":[0.9936674,0.00003276573,0.00001075705,0.006001693,0.0001095146,0.00001839948,0.000005382453,0.0000170254,0.0001370627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01624795,"threshold_uncertainty_score":0.5335382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673168488606041,"score_gpt":0.2954091284148435,"score_spread":0.2586774435287831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}