{"id":"W2301504663","doi":"10.1039/c5sc04252f","title":"An enzyme-activatable and cell-permeable Mn<sup>III</sup>-porphyrin as a highly efficient <i>T</i><sub>1</sub> MRI contrast agent for cell labeling","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Western University; Hospital for Sick Children; The Scarborough Hospital; SickKids Foundation; University of Toronto; Robarts Clinical Trials; Toronto Public Health","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; University of Toronto; Canada Foundation for Innovation; University of Toronto Scarborough; Ontario Institute for Cancer Research; Sick Kids Foundation; Heart and Stroke Foundation of Canada","keywords":"Porphyrin; Contrast (vision); Chemistry; Nuclear magnetic resonance; Cell; MRI contrast agent; Crystallography; Combinatorial chemistry; Gadolinium; Physics; Photochemistry; Biochemistry; Organic chemistry; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009210897,0.000263406,0.0003180181,0.00006666802,0.0004726717,0.0002826566,0.0006165337,0.00008456614,0.0001141281],"category_scores_gemma":[0.00008368715,0.0001807443,0.00007022914,0.0003623314,0.0007682037,0.0004994714,0.0001428952,0.00009215707,0.0001381542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000989397,"about_ca_system_score_gemma":0.0001739654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005094328,"about_ca_topic_score_gemma":0.000001936069,"domain_scores_codex":[0.9971466,0.00004066838,0.0003614993,0.0009665207,0.0005932821,0.0008914018],"domain_scores_gemma":[0.9985979,0.0002343218,0.0001202653,0.0004204434,0.0001824171,0.0004446167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008788717,0.0001986949,0.00001030121,0.00004715714,0.000001664567,0.000005078665,0.0002274468,0.0003064127,0.9982713,0.0003453547,0.0002055954,0.000293093],"study_design_scores_gemma":[0.001264111,0.0001476001,0.00001120121,0.0000582065,0.00002060636,0.00001497408,0.0001225029,0.004823353,0.9920845,0.0005052843,0.0006175192,0.0003301505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900733,0.0001479659,0.008247163,0.0002254736,0.000160915,0.0004137323,0.0001245178,0.0001146801,0.0004922224],"genre_scores_gemma":[0.996366,0.0000327343,0.002993651,0.000337418,0.000112219,0.00006099886,0.000008443833,0.00002111822,0.00006742814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006292659,"threshold_uncertainty_score":0.737054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206802634203421,"score_gpt":0.2275919626954345,"score_spread":0.2155239363534003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}