{"id":"W2301504663","doi":"10.1039/c5sc04252f","title":"An enzyme-activatable and cell-permeable Mn<sup>III</sup>-porphyrin as a highly efficient <i>T</i><sub>1</sub> MRI contrast agent for cell labeling","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Western University; Hospital for Sick Children; The Scarborough Hospital; SickKids Foundation; University of Toronto; Robarts Clinical Trials; Toronto Public Health","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; University of Toronto; Canada Foundation for Innovation; University of Toronto Scarborough; Ontario Institute for Cancer Research; Sick Kids Foundation; Heart and Stroke Foundation of Canada","keywords":"Porphyrin; Contrast (vision); Chemistry; Nuclear magnetic resonance; Cell; MRI contrast agent; Crystallography; Combinatorial chemistry; Gadolinium; Physics; Photochemistry; Biochemistry; Organic chemistry; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007477981,0.0002351831,0.0001493017,0.0000855383,0.0001067466,0.0002358112,0.0002532969,0.0002664784,0.0006139726],"category_scores_gemma":[0.00008405733,0.0001283285,0.00007535097,0.0001241499,0.0001846995,0.0002489029,0.0002092958,0.0002976754,0.0003916794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434888,"about_ca_system_score_gemma":0.0001544482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004334505,"about_ca_topic_score_gemma":0.0003931189,"domain_scores_codex":[0.9999557,0.000005764535,0.000002391272,0.00001557377,0.0000107607,0.000009879564],"domain_scores_gemma":[0.9999688,0.000004999066,0.000009075563,0.00000402877,0.000004606312,0.000008469898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001863356,0.000003794298,0.00003132578,0.00003253639,0.000001211746,0.00004065115,0.000007683127,0.00005356176,0.9978592,0.0002066272,0.00006778064,0.001676953],"study_design_scores_gemma":[0.000002361553,0.00002398597,0.0002323228,0.000001249759,0.00000337129,0.0001805818,0.000005073152,0.0004906448,0.9959125,0.00003642748,0.003109382,0.000002164966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9103399,0.005100666,0.07546806,0.0005342873,0.00009692882,0.0001243736,0.0005047563,0.0007887877,0.007042263],"genre_scores_gemma":[0.96163,0.001423059,0.0258345,0.00008156733,0.00001079825,0.00005172368,0.0002982977,0.00006914816,0.01060089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006139726,"threshold_uncertainty_score":0.002053976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206802634203421,"score_gpt":0.2275919626954345,"score_spread":0.2155239363534003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}