{"id":"W2301676073","doi":"10.1016/j.chom.2016.02.019","title":"Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":271,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; International Graduate School in Molecular Medicine Ulm; Leibniz-Gemeinschaft; Deutsche Forschungsgemeinschaft","keywords":"Biology; Infectivity; Virology; SAMHD1; Interferon; Effector; Guanosine; Viral envelope; GTPase; Virus; Gene; Cell biology; Genetics; RNA; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001616671,0.0002903391,0.0001659837,0.0001707265,0.0002501536,0.0002370982,0.000244146,0.000268606,0.001022229],"category_scores_gemma":[0.0001403011,0.0001258532,0.0001977619,0.00008342592,0.0002316007,0.00008265702,0.0002882039,0.0005478582,0.0002988207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004085088,"about_ca_system_score_gemma":0.0003206181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035946,"about_ca_topic_score_gemma":0.001756399,"domain_scores_codex":[0.9999068,0.00001867851,0.000003982301,0.00001196601,0.00002818266,0.00003049522],"domain_scores_gemma":[0.9999552,0.000008017943,0.00001118756,0.000003791832,0.00000374479,0.00001812556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365003,0.00005259939,0.0007671025,0.00005607378,0.00001395497,0.0002428856,0.00001066035,0.0001909377,0.9903293,0.0005209361,0.0003700199,0.007109107],"study_design_scores_gemma":[0.0001048788,0.0008647938,0.02690646,0.00002555958,0.00005315647,0.001307598,0.00004313515,0.00302101,0.9532963,0.000402956,0.01396163,0.00001244428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793483,0.009562421,0.004123827,0.0004770547,0.0001305115,0.00008022103,0.0003291932,0.0001552682,0.005793259],"genre_scores_gemma":[0.9936681,0.001523079,0.001811445,0.0001427616,0.00002324969,0.00002495477,0.0004487511,0.000009296077,0.002348325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035946,"threshold_uncertainty_score":0.003419638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722331992327688,"score_gpt":0.2523786241549479,"score_spread":0.235155304231671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}