{"id":"W2301676073","doi":"10.1016/j.chom.2016.02.019","title":"Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":271,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; International Graduate School in Molecular Medicine Ulm; Leibniz-Gemeinschaft; Deutsche Forschungsgemeinschaft","keywords":"Biology; Infectivity; Virology; SAMHD1; Interferon; Effector; Guanosine; Viral envelope; GTPase; Virus; Gene; Cell biology; Genetics; RNA; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002675978,0.0002409404,0.0003277886,0.000190906,0.0001442173,0.00001754041,0.0002559714,0.0002434292,0.001992928],"category_scores_gemma":[0.00003519144,0.0001649755,0.000121918,0.00014954,0.0002722586,0.0002121693,0.0002127371,0.0002289135,0.006763603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227323,"about_ca_system_score_gemma":0.0001211888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001384655,"about_ca_topic_score_gemma":0.00003752911,"domain_scores_codex":[0.9983796,0.0002253654,0.0002945485,0.0004749376,0.00004446694,0.0005810708],"domain_scores_gemma":[0.9990933,0.00007309142,0.0001356326,0.0005343773,0.00009177675,0.00007180159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001983421,0.0005995261,0.005844482,0.0000437816,0.00009619728,0.00001037348,0.0004549522,3.313022e-8,0.9840398,0.00001819067,0.003566033,0.005128236],"study_design_scores_gemma":[0.002264054,0.0009401113,0.001097835,0.0001451885,0.00001928708,0.00001486845,0.00007162272,1.017532e-7,0.9745949,0.00001681642,0.02064394,0.0001912572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964295,0.0005294178,0.0001156318,0.0002589194,0.0002005355,0.0005498591,0.0004585266,0.000060424,0.001397204],"genre_scores_gemma":[0.9830962,0.00004951509,0.00008818653,0.00002375606,0.00002997698,0.00004529763,0.00008902991,0.00002948504,0.0165486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0170779,"threshold_uncertainty_score":0.9989194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722331992327688,"score_gpt":0.2523786241549479,"score_spread":0.235155304231671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}