{"id":"W2301681798","doi":"10.18632/oncotarget.8006","title":"Genomic markers of panitumumab resistance including ERBB2/HER2 in a phase II study of KRAS wild-type (wt) metastatic colorectal cancer (mCRC)","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"BC Cancer Agency; Cancer Research UK; BC Cancer Foundation; Amgen; Amgen Canada; Canada's Michael Smith Genome Sciences Centre","keywords":"KRAS; Panitumumab; Colorectal cancer; Medicine; Internal medicine; Oncology; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001432786,0.0006306965,0.0009121161,0.0003040826,0.0003412825,0.0006518026,0.0003750383,0.000526942,0.0009403945],"category_scores_gemma":[0.0008780604,0.0006307175,0.0004474613,0.0004088807,0.0005643452,0.0003906202,0.0002561754,0.001011193,0.0002285263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006926447,"about_ca_system_score_gemma":0.0009224566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001586272,"about_ca_topic_score_gemma":0.003874583,"domain_scores_codex":[0.9996405,0.000159006,0.00002029195,0.00007249996,0.00005745972,0.00005035474],"domain_scores_gemma":[0.9993004,0.0001442872,0.0001640218,0.0000624033,0.0000657261,0.0002630845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2388103,0.03013882,0.5534774,0.000335542,0.00126028,0.000925226,0.0006259106,0.002295328,0.1132424,0.0001548228,0.001361446,0.05737254],"study_design_scores_gemma":[0.0402681,0.2441167,0.697167,0.00002924954,0.0009975808,0.001768402,0.0002679402,0.002767466,0.01020596,0.0001093017,0.002250863,0.00005134707],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991997,0.0002655982,0.00006864464,0.00003632754,0.000007010044,0.0001486682,0.0001297765,0.000004484901,0.0001397305],"genre_scores_gemma":[0.9986963,0.0002037348,0.0002566764,0.00007673533,0.00001538888,0.0001056617,0.0003991486,0.000003993642,0.0002424117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586272,"threshold_uncertainty_score":0.007577419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03640587464814483,"score_gpt":0.3447157668549588,"score_spread":0.308309892206814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}