{"id":"W2301786365","doi":"10.1016/j.ydbio.2016.02.031","title":"A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2 /insulin signaling and by the TGF-β/Sma/Mab pathway","year":2016,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research; Canada Research Chairs","keywords":"Biology; Enhancer; Caenorhabditis elegans; Activator (genetics); Vitellogenin; Transcription factor; Repressor; Molecular biology; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000571225,0.0006402284,0.0004676139,0.00004427445,0.0006007198,0.0001389886,0.000617005,0.0005265276,0.0001361097],"category_scores_gemma":[0.0000601997,0.0003609226,0.00008262929,0.0002011952,0.001216093,0.0000187329,0.0004099684,0.000316851,0.0000138452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007210655,"about_ca_system_score_gemma":0.00008888858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002241423,"about_ca_topic_score_gemma":0.00009851172,"domain_scores_codex":[0.9967197,0.000435088,0.0006686632,0.001271161,0.0002030273,0.0007023181],"domain_scores_gemma":[0.9985244,0.0002920282,0.0003073314,0.000590064,0.0001057939,0.000180358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001583192,0.00006047556,0.002025445,0.000005156294,0.0001946627,0.000002803395,0.001035361,3.312592e-7,0.8918151,0.000008113553,0.08498028,0.01971398],"study_design_scores_gemma":[0.001214157,0.0001550085,0.0008685201,0.00002752333,0.00003383533,0.00009972793,0.0002532506,0.00001816542,0.8388896,0.0001664846,0.1577496,0.000524166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476496,0.04662503,0.001176754,0.002169344,0.0002332856,0.0005631839,0.001467977,0.00005718497,0.00005764933],"genre_scores_gemma":[0.9846995,0.01009402,0.0006328719,0.001927412,0.0001866616,0.00006597846,0.001496012,0.00008579043,0.0008117338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07276929,"threshold_uncertainty_score":0.9998842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008408399550926404,"score_gpt":0.1975432994740798,"score_spread":0.1891348999231534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}