{"id":"W2301786365","doi":"10.1016/j.ydbio.2016.02.031","title":"A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2 /insulin signaling and by the TGF-β/Sma/Mab pathway","year":2016,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research; Canada Research Chairs","keywords":"Biology; Enhancer; Caenorhabditis elegans; Activator (genetics); Vitellogenin; Transcription factor; Repressor; Molecular biology; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478376,0.0004998966,0.0002599194,0.0004550753,0.0002747647,0.0002115216,0.000273374,0.000401545,0.003885946],"category_scores_gemma":[0.0001191334,0.0005553632,0.0004426485,0.0001287284,0.0003857441,0.0001385353,0.0003700331,0.0009524286,0.00141496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733393,"about_ca_system_score_gemma":0.0004164313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178521,"about_ca_topic_score_gemma":0.00445154,"domain_scores_codex":[0.9998437,0.00001032942,0.000005913623,0.00006568036,0.0000383622,0.00003590088],"domain_scores_gemma":[0.9998536,0.00003348802,0.00002671283,0.00001146956,0.00001138975,0.00006326591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005177907,0.00001568272,0.00007483256,0.00001793883,0.000002020276,0.00005624511,0.00001272358,0.00001864425,0.9979556,0.0001327,0.00007837443,0.001583538],"study_design_scores_gemma":[0.0001062784,0.0002295259,0.02585347,0.00004338946,0.00002664354,0.0006226481,0.00004035678,0.0007925431,0.9536616,0.0001502244,0.01845182,0.00002140242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9380193,0.001846879,0.0419618,0.0002795455,0.0003708109,0.0002618365,0.002483428,0.001382829,0.01339364],"genre_scores_gemma":[0.930416,0.0007997756,0.02156788,0.0002987929,0.00006404194,0.0001980281,0.005005364,0.0003684913,0.04128161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003885946,"threshold_uncertainty_score":0.01299983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008408399550926404,"score_gpt":0.1975432994740798,"score_spread":0.1891348999231534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}