{"id":"W2302198697","doi":"10.1111/jcmm.12827","title":"Subthreshold nitric oxide synthase inhibition improves synergistic effects of subthreshold <scp>MMP</scp>‐2/<scp>MLCK</scp>‐mediated cardiomyocyte protection from hypoxic injury","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Contractility; Myosin light-chain kinase; Nitric oxide synthase; Chemistry; Nitric oxide; Hypoxia (environmental); Myocyte; Phosphorylation; Contraction (grammar); Dephosphorylation; Pharmacology; Biochemistry; Endocrinology; Biology; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212106,0.0004047829,0.000551723,0.0001347334,0.00008434302,0.0001780423,0.0002208594,0.0002448119,0.0006795057],"category_scores_gemma":[0.00008133623,0.0001035368,0.0002908203,0.00007120548,0.0001737944,0.0001820294,0.0002157426,0.000733892,0.000152832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001213444,"about_ca_system_score_gemma":0.0002055036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002467866,"about_ca_topic_score_gemma":0.0007444002,"domain_scores_codex":[0.9998921,0.00001782498,0.00001254514,0.00002228351,0.00002377818,0.00003150899],"domain_scores_gemma":[0.9999297,0.00000782202,0.00001811446,0.000006182619,0.000007154776,0.00003108634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006706062,0.0001302587,0.00009450469,0.00006262077,0.00001208079,0.0000521792,0.000009094033,0.00007845997,0.9974131,0.00002340757,0.00004507833,0.00140861],"study_design_scores_gemma":[0.00009445337,0.00275599,0.003386596,0.000009569867,0.00004223865,0.0001882962,0.00001942799,0.0007258322,0.99161,0.00002791237,0.001131666,0.000008022321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969279,0.00160516,0.0007929906,0.00006574595,0.00004720457,0.00002179868,0.0000973689,0.00004317712,0.0003986222],"genre_scores_gemma":[0.9969417,0.0009674118,0.0009373271,0.00004626135,0.00001924049,0.00003670272,0.0001725316,0.00000793615,0.0008708204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006795057,"threshold_uncertainty_score":0.002273142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005760835949720832,"score_gpt":0.2111303670485965,"score_spread":0.2053695310988757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}