{"id":"W2302361826","doi":"10.1371/journal.pone.0144890","title":"The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; Université Laval","keywords":"In vivo; Cancer research; In vitro; Pharmacology; Ovarian cancer; Pancreatic cancer; Pharmacokinetics; Growth inhibition; Medicine; Internal medicine; Chemistry; Biology; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549948,0.000292444,0.0002266843,0.0002029962,0.00007825463,0.0001362226,0.00009369424,0.0001751083,0.001009153],"category_scores_gemma":[0.0001039752,0.0001035952,0.0002102021,0.0002057326,0.0001196348,0.0001102746,0.00009575763,0.0004302278,0.0001784585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001174996,"about_ca_system_score_gemma":0.0001861688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007497,"about_ca_topic_score_gemma":0.001186027,"domain_scores_codex":[0.9999431,0.00001759425,0.000005537363,0.000008532512,0.00001160697,0.00001365403],"domain_scores_gemma":[0.9999393,0.00001927425,0.0000127894,0.00000804618,0.000007459086,0.00001309053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004884864,0.0003100764,0.0003441981,0.0001280602,0.0000132393,0.00007760357,0.00004506556,0.0006549906,0.992334,0.00007149517,0.0001550696,0.005377796],"study_design_scores_gemma":[0.0001105329,0.006808813,0.006087418,0.00001385554,0.00005462935,0.0003920726,0.00003750165,0.001103071,0.9819697,0.00002929192,0.00338493,0.00000821598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944435,0.002439888,0.001064677,0.00006965465,0.0000159522,0.0000448518,0.000328473,0.00004746918,0.001545555],"genre_scores_gemma":[0.9932505,0.002544335,0.001427925,0.00003456459,0.00001022949,0.00003989264,0.0007750221,0.0000158852,0.001901734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009153,"threshold_uncertainty_score":0.003376007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.052004199202051,"score_gpt":0.2693109018611833,"score_spread":0.2173067026591323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}