{"id":"W2302383556","doi":"10.1021/acs.biomac.5b01642","title":"Stability and Biodistribution of Thiol-Functionalized and <sup>177</sup>Lu-Labeled Metal Chelating Polymers Bound to Gold Nanoparticles","year":2016,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation; University of Toronto; Canadian Cancer Society","keywords":"DOTA; Biodistribution; Chemistry; PEG ratio; Chelation; Nuclear chemistry; Polyethylene glycol; Thiol; Radiochemistry; Conjugated system; Dithiothreitol; Polymer chemistry; Polymer; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188353,0.0001358301,0.0002246497,0.00002979677,0.00008494777,0.00001640837,0.00004472112,0.0000743641,0.0001524055],"category_scores_gemma":[0.0002279123,0.00009706473,0.00004994867,0.000181923,0.0003271473,0.00006023738,0.00005083216,0.00004856315,0.000006220595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003993187,"about_ca_system_score_gemma":0.0000406798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001554375,"about_ca_topic_score_gemma":9.318967e-7,"domain_scores_codex":[0.9990178,0.00003710021,0.0002744617,0.0003081064,0.0001604041,0.0002021013],"domain_scores_gemma":[0.9993052,0.0001333889,0.00006341889,0.0001812582,0.00007615494,0.0002405181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977686,0.0001021302,0.002295243,0.00007721085,0.00006582076,0.000002924431,0.00006538237,9.249894e-8,0.9858809,0.0006197279,0.00003465161,0.01065812],"study_design_scores_gemma":[0.001416834,0.00009943111,0.00702434,0.00005707476,0.0001278659,0.00004897607,0.0001361038,0.00007870459,0.9896963,0.0002269098,0.0009681164,0.0001193419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959173,0.0007668225,0.0002489068,0.002195543,0.0000101003,0.000259501,0.0001776671,0.00004357394,0.0003805705],"genre_scores_gemma":[0.9989885,0.00003630623,0.0006476599,0.0000955728,0.0000349386,0.00003179563,0.00002542019,0.000009132276,0.000130651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01053878,"threshold_uncertainty_score":0.3958185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02752389912057719,"score_gpt":0.2912112858232498,"score_spread":0.2636873867026727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}