{"id":"W2302509459","doi":"10.1007/s10637-016-0340-0","title":"Convection-enhancement delivery of liposomal formulation of oxaliplatin shows less toxicity than oxaliplatin yet maintains a similar median survival time in F98 glioma-bearing rat model","year":2016,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Oxaliplatin; Medicine; Glioma; Toxicity; Radiation therapy; Chemotherapy; Liposome; Pharmacology; Drug delivery; Internal medicine; Colorectal cancer; Cancer; Cancer research; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243787,0.0002365457,0.0002202526,0.0001299138,0.0001059154,0.0001196881,0.0001554658,0.0001759386,0.000627429],"category_scores_gemma":[0.00006609934,0.00007525158,0.0001935037,0.0001195036,0.0001448385,0.00025735,0.00008518656,0.0003088459,0.0001043004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209548,"about_ca_system_score_gemma":0.0002456993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265412,"about_ca_topic_score_gemma":0.001240063,"domain_scores_codex":[0.9999319,0.00000659987,0.000005792127,0.00001952903,0.00001236095,0.00002366039],"domain_scores_gemma":[0.9999603,0.000005054594,0.00001445117,0.000004637524,0.000006044453,0.000009533423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003373661,0.00007080181,0.00009816751,0.0000296698,0.000003827162,0.00002218612,0.00001715269,0.00007003148,0.9974322,0.00006141303,0.00006021118,0.001797098],"study_design_scores_gemma":[0.00001200325,0.0004393224,0.0007488668,0.000001089745,0.000008400558,0.00005007965,0.000005827215,0.0003652652,0.997744,0.000007587666,0.0006147478,0.000002721598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963344,0.0007167117,0.002193416,0.00004618588,0.00002684427,0.00001901744,0.0001051279,0.00005750623,0.0005008009],"genre_scores_gemma":[0.9952053,0.0004297441,0.001804091,0.00002484442,0.000006751311,0.00002596306,0.0002571317,0.0000159737,0.002230236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265412,"threshold_uncertainty_score":0.002516091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02465148526066414,"score_gpt":0.2384144321960588,"score_spread":0.2137629469353946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}